Recombinant Rat Cytochrome b reductase 1 (Cybrd1)

in vitro E.coli expression system

中文名稱：

Recombinant Rat Cytochrome b reductase 1(Cybrd1)
貨號：

CSB-CF006326RA
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Cybrd1
Uniprot No.：

Q5RKJ2
別名：

Cybrd1; Dcytb; Plasma membrane ascorbate-dependent reductase CYBRD1; Cytochrome b reductase 1; Duodenal cytochrome b
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-286
氨基酸序列

MAMEGYRGFLGLLVSALLVGFLSVIFVLIWVLHFREGLGWDGGALEFNWHPVLAVTGFVF IQGIAIIVYRLPWTWKCSKFLMKSIHAGLNAVAAILAIISVVAVFDYHNVRKIPHMYSLH SWVGLTVLILYIQQLVVGFFIFLLPWAPPSLRAIVMPIHVYSGLLLFGTVIATVLMGVTE KLFFVLKNPSYHSFPPEGVFTNTLGLLILVFGALIFWIVTRPQWKRPREPGSIPLQLNGG NADGMEGAIAISSAHNMDAADAELSSEGAARKRTLGLVDTGQRSTM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes. It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood. May also act as a ferrireductase in airway epithelial cells. May also function as a cupric transmembrane reductase.
基因功能參考文獻：
1. Data suggest that expression of Cybrd1 in intestinal mucosa can be regulated by dietary factors; here, expression of Cybrd1 in mucosa of duodenum is up-regulated by prebiotic supplement, inulin, in iron-deficiency anemia. PMID: 25745840
2. There is an increase in hippocampal expression of duodenal Cybrd1 following kainic acid-induced excitotoxicity. PMID: 23597830
3. Results suggest that the presence of duodenal cytochrome b (Dcytb) in airway epithelial cells and its regulation by iron may contribute to pulmonary cytoprotection [Dcytb]. PMID: 16510471
亞細胞定位：

Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
組織特異性：

Highly expressed in all regions of the small intestine and colon studied in suckling animals. However, after weaning, when iron absorption declines significantly, strong expression is retained only in the duodenum. Also expressed in respiratory epithelium
數據庫鏈接：

KEGG: rno:295669

STRING: 10116.ENSRNOP00000012942

UniGene: Rn.203500