Recombinant Rat Basigin (Bsg)

in vitro E.coli expression system

中文名稱：

Recombinant Rat Basigin(Bsg)
貨號：

CSB-CF002831RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Bsg
Uniprot No.：

P26453
別名：

Bsg; Basigin; Glycoprotein CE9; OX-47 antigen; CD antigen CD147
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

22-388
氨基酸序列

AAGFLKAPMSQEQWAGGSVVLHCEAVGSPMPEIQWWFEGNEPNDSCSQLWDGARLDRVHIHATYRQHAASTLSVDGLAAEDTGTYECRASSDPDRNHLTRPPRVKWVRAQASVVVLEPGTIVTSVQEVDSKTQLTCFLNSSGIDIVGHRWMRGGKVLQEDTLPDLQMKYTVDADDRSGEYSCIFLPEPVGRGNINVEGPPRIKVGKKSEHASEGEFVKLICKSEASHPPVDEWVWFKTSDTGDQTISNGTEANSKYVIISTPELSELIISDLDMNVDPGTYVCNATNSQGSARETISLRVRSRLAALWPFLGIVAEVLVLVTIIFIYEKRRKPDQTLDEDDPGAAPLKGSGSHLNDKDKNVRQRNAT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Essential for normal retinal maturation and development. Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors.; Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells. Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1 and SLC16A3 to the plasma membrane. Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling. Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells. Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids.
基因功能參考文獻：
1. EMMPRIN overexpressing subventricular zone neural progenitor cells invade ischemic cortical tissue more efficiently than controls. PMID: 28716558
2. Upregulation of extracellular matrix metalloproteinase inducer (OX47) in rat dorsal root ganglion contributes to the development of mechanical allodynia after nerve injury. PMID: 26697232
3. EMMPRIN regulates pressure ulcer healing by controlling the collagen content and angiogenesis rather than MMPs activity. PMID: 26261551
4. EMMPRIN expression was increased following fluid percussion injury. EMMPRIN increased expression was temporally correlated with an increase in MMP-9 levels. CD147 and MMP-9 may play a role in vascular injuries after TBI. PMID: 24968091
5. EMMPRIN/CD147-regulated metalloproteinases MMP-2 and MMP-14, associated with low MMP-3, appear as the main characteristics of extracellular matrix remodeling in early overused tendons. PMID: 23404084
6. basigin may be involved in acute myocardial ischemia following continual ischemia for >30 min. PMID: 23525302
7. EMMPRIN mediates induction of uterine and vascular matrix metalloproteinases during pregnancy. PMID: 23856290
8. EMPRIN and cyclophilin-A play roles in the maturation of dental hard tissue and the formation of a molar eruption pathway. PMID: 22139963
9. EMMPRIN and VEGF may play a role in radiation injuries of the central nervous system after gamma knife surgery PMID: 22379341
10. High Extracellular matrix metalloproteinase inducer is associated with pediatric medulloblastoma. PMID: 21448785
11. Basigin was involved in myocardium pathophysiology 30 minutes after myocardial ischemia. PMID: 20369476
12. Molecular mass in cauda spermatozoa was approximately 28,000-26,000 Dalton. Capacitation induces minor posttranslational modifications in structure. Facilitates sperm-oocyte interactions. PMID: 14645104
13. identified a single leucine (252) as the basolateral targeting motif in the cytoplasmic tail of CD147 PMID: 15215314
14. Basigin espression profiles in induced-ovulation/corpus luteum regression models are similar to those in naturally cycling mature rats and significantly augmented to gonadotropin. PMID: 15758150
15. These results raise the possibility that the increased expression of EMMPRIN, the increase in MMPs and the damage of the basal lamina following cerebral ischemia are connected and part of a network of related changes. PMID: 16029217
16. bleomycin-induced lung injury is associated with an increase in CD147 expression and MMP activity, particularly in alveolar epithelial cells. our data exclude any functional interaction between CD147 & alveolar epithelial caveolin-1. PMID: 16733664
17. These findings suggest that in the myocardium the regulated expression of EMMPRIN is a determinant of MMP activity and may thus play a role in myocardial remodeling. PMID: 17869266
18. at low to moderate doses of rt-PA the microvascular basal lamina collagen IV was protected, probably due to inhibition of MMP-2 and MMP-9 by the upregulation of TIMP1, TIMP2, and EMMPRIN PMID: 18000599
19. These findings suggest potential roles for basement membrane in the transcriptional regulation of tracheal epithelial EMMPRIN. PMID: 18243135
20. Extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinases (MMP2/9) as regulators of tumor-host interaction in a spontaneous metastasis model in rats. PMID: 18769934
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亞細胞定位：

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein.
組織特異性：

[Isoform 2]: Expressed in the skeletal muscle, liver, small intestine, kidney, testis, brain, heart and spleen. Also present in various immature cells and endothelia.
數(shù)據(jù)庫鏈接：

KEGG: rno:25246

STRING: 10116.ENSRNOP00000011275

UniGene: Rn.2269