Recombinant Mouse Histamine H4 receptor (Hrh4)

in vitro E.coli expression system

中文名稱：

小鼠Hrh4重組蛋白
貨號：

CSB-CF842068MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Hrh4
Uniprot No.：

Q91ZY2
別名：

Hrh4; Histamine H4 receptor; H4R; HH4R
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-391
氨基酸序列

MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAIS DFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAV SYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTIT MLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSN PGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRG RKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLY PLCHRRFQKAFWKILCVTKQPALSQNQSVSS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
基因功能參考文獻(xiàn)：
1. colonic mast cells-derived histamine initiates granulocyte infiltration into the colonic mucosa through H4R PMID: 29363669
2. This study demonstrated that the phenotype of H4R(-)/(-) mice leads to increased neuropathic pain hypersensitivity promoting an overactivation of spinal ERK-CREB pathway in DbetaH expressing neurons without modifying the innervation of the hind paw skin and integrity of the primary sensory neurons. PMID: 29107625
3. H4R ligands have a beneficial effect in a model of lung fibrosis in the mouse, thus indicating that H4R antagonists or inverse agonists could be a novel therapeutic strategy for lung inflammatory diseases. PMID: 27475884
4. Results illustrate that histamine H4 receptors (H4R) modulates various neurophysiological functions such as locomotor activity, anxiety, nociception and feeding behaviour, confirming the importance of the integrity and functionality of neuronal H4R in the histaminergic regulation of neuronal functions. PMID: 27899280
5. These results identify the H4R as a new target controlling NK cell migration and NK cell-dendritic cell interaction in the skin during early allergic inflammation. These results further suggest that blocking the H4R in the skin might be beneficial in diseases like atopic dermatitis. PMID: 27155791
6. Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis PMID: 26440543
7. H4 receptor expression plays a role in pathological vessel leakage associated with choroidal neovascularization PMID: 24787705
8. These results indicate a proinflammatory role of histamine via H4R in inflammatory bowel disease. PMID: 26365468
9. Functional H4 receptors increasing (35)S-GTPgammaS binding and/or decreasing noradrenaline release are not found in human, guinea pig or mouse cortex PMID: 25300787
10. in experimental asthma in mice the H4 receptor specifically regulates activation of dendritic cells during sensitization, while in the effector phase the H4 receptor is active in cells involved in the activation of eosinophils, and possibly other cells. PMID: 25501767
11. involved in the pathogenesis and progression of rheumatoid arthritis PMID: 24402309
12. These results reveal a crucial role for H1- and H4-receptors for Th2 migration and cytokine secretion in a Th2-driven model of skin inflammation. PMID: 24503582
13. the role of H4 receptors in immune disease is context-specific, depending on the animal model used and the complement of H4 receptor-expressing cells; H4 receptor blockade was detrimental in experimental autoimmune encephalomyelitis PMID: 23735232
14. The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis. PMID: 24126456
15. H4R expression on murine keratinocytes was detected after stimulation with LPS and peptidoglycan. PMID: 23932072
16. HR4 is most important for the development of rheumatoid arthritis. PMID: 23545338
17. the present study shows that H4 receptors potentially play a role in IgE induced FcepsilonRI upregulation PMID: 23850674
18. Acting via its H4 receptors, histamine impedes lipopolysaccharide-induced microglia migration and interleukin (IL)-1beta release under inflammatory challenge. PMID: 22569158
19. development of allergic rhinitis proceeded in two distinct stages: histamine release from FcepsilonRI-activated mast cells, followed by histamine-mediated recruitment of H(4)R-expressing basophils to the nasal cavity and activation through FcepsilonRI. PMID: 23241885
20. analysis of fragment optimization and analysis of binding kinetics for ligand based design of novel histamine H receptor antagonists PMID: 22153663
21. The majority of hypertrophic ATDC5 chondrocytes express H4R, suggesting that this receptor is associated with the differentiation of chondrocytes into hypertrophic cells. PMID: 22065367
22. Data suggest that a combined pharmacological targeting of histamine H(1) and H(4) receptors could be taken into consideration as an option for the prevention of asthma and maybe other allergic diseases. PMID: 22272324
23. Histamine Hrh4-deficient mice, despite having equivalent T effector cell responses, develop more severe allergic encephalomyelitis, augmented neuroinflammation, and increased blood-brain barrier permeability compared with wild-type mice. PMID: 22147765
24. enhances LPS-induced IL-6 production in mast cells PMID: 21469095
25. Langerhans cells express a functional H(4)R and point towards a possible pathogenic relevance of the H(4)R in inflammatory and allergic diseases. PMID: 19958313
26. Therapeutic H4R antagonism can significantly ameliorate allergen induced, Th2 cytokine driven pathologies such as lung remodeling and airway dysfunction in asthma. PMID: 20573261
27. a sudy of the expression of H4R protein in mice and its possible role in dendritic cell function namely antigen presentation PMID: 19997860
28. Utilising A new immunological probe, new evidence is provided for oligomeric mH(4)Rs and the presence of H(4) receptors on a subpopulation of murine motor neurons PMID: 20020316
29. Superinduction of the histamine H(4) receptor gene in the spleen is transcriptionally controlled by NF-kappa B; stimulation of this receptor is involved in sepsis-induced splenic apoptosis through counteraction of the antiapoptotic action of NF-kappaB. PMID: 20008488
30. The effect of H(4)R antagonism on dendritic cell migration in vivo may be an indirect result of the reduction in tissue cytokines and chemokines or a direct effect on chemotaxis PMID: 19907432
31. show that progenitor cell populations express this receptor subtype on transcriptional and protein levels and respond to its agonists by reduced growth factor-induced cell cycle progression that leads to decreased myeloid, erythroid and lymphoid formation PMID: 19662098
32. Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells. PMID: 12626656
33. Mouse eosinophils express H4. CCL16 induced pertussis toxin-sensitive calcium mobilization and chemotaxis only in murine L1.2 cells expressing H4. PMID: 15265943
34. We investigated the potential role of H4R in development of allergic asthma in a murine model. PMID: 17548646
35. Results describe hepatic gene expression in genetically histamine H4 receptor deficient mice in normal and inflammatory conditions. PMID: 17806177
36. Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors. PMID: 18635748
37. Histamine-induced functional recovery of invariant natural killer (NK)T cells in histamine-free histidine decarboxylase-deficient mice is mediated mainly through the histamine H4 receptor. PMID: 19155466
38. Role of histamine H(4) receptor in allergic conjunctivitis in mice is presented. PMID: 19249296
39. Histamine H4 receptors are functionally expressed on neurons, which has major implications for the therapeutic potential of these receptors in neurology and psychiatry. PMID: 19413571
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
數(shù)據(jù)庫鏈接：

KEGG: mmu:225192

STRING: 10090.ENSMUSP00000041061

UniGene: Mm.207073