Recombinant Mouse Histamine H1 receptor (Hrh1)

in vitro E.coli expression system

中文名稱：

小鼠Hrh1重組蛋白
貨號：

CSB-CF010737MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Hrh1
Uniprot No.：

P70174
別名：

Hrh1; Bphs; Histamine H1 receptor; H1R; HH1R
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達(dá)區(qū)域：

1-488
氨基酸序列

MSLPNTSSASEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVRSERKLHT VGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFI LCIDRYRSVQQPLRYLRYRTKTRASATILGAWFLSFLWVIPILGWHHFTPLAPELREDKC ETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPTFLEIKLR SEDAKEGAKKPGKESPWGVQKRPSRDPTGGLDQKSTSEDPKVTSPTVFSQEGERETVTRP CFRLDVMQTQPVPEGDARGSKANDQTLSQPKMDEQSLSTCRRISETSEDQTLVDRQSFSR TTDSDTSIEPGLGKVKARSRSNSGLDYIKVTWKRLRSHSRQYVSGLHLNRERKAAKQLGC IMAAFILCWIPYFIFFMVIAFCNSCCSEPVHMFTIWLGYINSTLNPLIYPLCNENFKKTF KKILHIRS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Involved in circadian rhythm of locomotor activity and exploratory behavior. Also involved in responsiveness to pertussis toxin through its control of susceptibility to histamine hypersensitivity and enhancement of antigen-specific delayed-type hypersensitivity responses.
基因功能參考文獻(xiàn)：
1. Data (including data from studies in knockout mice) suggest that sleep-promoting effect of dietary supplement rice bran is dependent on Hrh1 antagonism; rice bran fully inhibits Hrh1 agonist-induced increase in action potential frequency in tuberomammillary nucleus neurons. PMID: 28722302
2. Study showed that the sleep-wake cycle in H1-/- mice was affected both quantitatively and qualitatively: long-term abolition of histamine impairs cortical EEG, affects sleep-wake qualities and causes sleepiness facing behavioral challenges PMID: 26723880
3. this study shows that the histamine 1 receptor might be useful therapeutic target for treatment of metal allergy PMID: 27035718
4. Sympathetic tone changed in H1R-, but not H2R- or H3R-null mice. PMID: 25680462
5. The results of this study suggest that H1R deficiency in mice is associated with pronounced deficits in hippocampus-dependent spatial learning and memory. PMID: 24862254
6. These results reveal a crucial role for H1- and H4-receptors for Th2 migration and cytokine secretion in a Th2-driven model of skin inflammation. PMID: 24503582
7. histamine receptor H1 and histamine receptor H2 reciprocally regulate inflammation in the ligation-induced arteriosclerosis PMID: 24200155
8. Histamine demonstrably inhibited ACh-induced sweating in both mice and humans via H1R-mediated signaling. PMID: 23900020
9. Histamine H1 receptors (but not H2) mediate emotional memory consolidation impairment. PMID: 22986235
10. Histamine H1 receptors in the amygdala are not involved in anxiety-like behavior but are involved in emotional memory. PMID: 22772356
11. This study provides a potential mechanism of H1R-mediated signaling and NF-kB pathway crosstalk in allergic inflammationptor PMID: 23075496
12. Neuronal damage is significantly increased in H1R knock-out mice following status epilepticus. PMID: 22348791
13. Histamine H1 Receptor expression by CD11B(+) cells is not required for susceptibility to experimental allergic encephalomyelitis. PMID: 23121973
14. An increase in regulatory T cells was observed, yet these cells were incapable of controlling myocarditis in H(1)R(-/-) mice. an increase in regulatory T cells was observed, yet these cells were incapable of controlling myocarditis in H(1)R(-/-) mice. PMID: 22078271
15. histamine signaling through the H1R on dendritic cells is an important early event conditioning the quality of the skin effector immune response. PMID: 21269673
16. These data suggest that histamine H1 and H2 receptor signaling may regulate glucose and lipid metabolism and development of hyperlipidemia-induced nonalcoholic steatohepatitis. PMID: 20566747
17. endothelial H(1)R expression reduces BBB permeability, suggesting that endothelial H(1)R signaling may be important in the maintenance of cerebrovascular integrity PMID: 20956310
18. The study suggest that H1 receptors play a pivotal role in the regulation of seizure intensity and duration as well as seizure-induced neuronal damage in the immature P9 mice. PMID: 20359868
19. Regulation of sleep/wake states is completely achieved by OX(2)R-expressing neurones without involving H(1)R-mediated pathways. Maintenance of basal physiological sleep/wake states is fully achieved without both H(1) and OX(1) receptors. PMID: 19694625
20. H1 receptors have a role in the circadian variation in V(E) through control of acid-base status and metabolism in mice. PMID: 20217356
21. Histamine H1 receptor activation drives the formation of atherosclerotic lesions through an increased vascular permeability for LDL, which is associated with an enhanced secondary aortic and systemic inflammation. PMID: 20203300
22. H1R-/- mice were not protected against K/BxN serum-induced arthritis. PMID: 19762454
23. Histamine H1 receptors play an important role in nasal allergy symptoms induced by histamine in a study comparing histamine H1 receptor-deficient mice with wild-type. PMID: 12095164
24. congenic mapping links Bphs to the histamine H1 receptor gene(Hrh1); natural alleles of Hrh1 control both the autoimmune T cell and vascular responses regulated by histamine after Bordetella pertussis toxin sensitization PMID: 12142541
25. Bphs/Hrh1 plays a role in the genetic control of responsiveness to pertussis toxin. PMID: 12595443
26. histamine H(1)-R signaling pathway may be independent or downstream of the POMC/MC-4R signaling. PMID: 12746338
27. presence of histamine h1 receptor but not histamine h2 receptor was found in undifferentiated embryonic stem cells PMID: 12755409
28. Histaminergic mechanisms through H1 receptors play a crucial role not only in amygdaloid kindled seizures but also in the development of amygdaloid kindling. PMID: 15030492
29. histamine H(1)-Rs are crucial for the regulation of feeding rhythm and in mediating the effects of leptin PMID: 15331534
30. Histaminergic neurons protect the developing hippocampus from KA-induced neuronal damage, with regulation of neuronal survival being at least partly mediated through H1 receptors. PMID: 16436594
31. Central histamine contributes via the H1 receptor to changes in metabolic rate during hypoxia to increasehypoxic ventilatory decline in conscious mice. PMID: 16540381
32. Data establish a role for histamine and histamine type 1 receptors in promoting the migration of Th2 cells into sites of allergen exposure. PMID: 16680192
33. role of histamine H1 receptors in airway allergic inflammation; findings show that histamine plays an important role via H1 receptors in the development of T helper type 2 responses to enhance airway inflammation PMID: 16685135
34. Histamine effect was mediated by activation of histamine H1 and H2 receptors that induced inward currents and depolarization. PMID: 16738217
35. histamine modulates ventilation by affecting metabolism and arousal state via H1 receptors PMID: 16875510
36. The results of this study demonstrates that both H1 is involved in learning and memory processes for which the frontal cortex, amygdala and hippocampus interact. PMID: 17145090
37. Histamine H1 receptors are upregulated during bone marrow regeneration in mice. PMID: 17420012
38. Cytokine-induced endothelial intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expressionwas inhibited by tecastemazole in a manner independent of H1 receptor antagonism. PMID: 17517105
39. Data suggest that histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal interferon-gamma production in mice. PMID: 17965772
40. The motivational effects of novelty are diminished in histamine H1-receptor knock- out mice, possibly due to a dysfunctional brain reward system. PMID: 18331338
41. Results describe the roles of histamine H1 receptors on cognition PMID: 18345498
42. Initial increases in ventilation were augmented during dark periods. H1 receptors had no major relationship with circadian variation, but affected the declined phase. PMID: 18358081
43. data are the first to demonstrate that structural polymorphisms influencing cell surface expression of a G protein-coupled receptor in T cells regulates immune functions and autoimmune disease susceptibility PMID: 18490747
44. ELM and long-term PM are impaired in the homozygous H1R-KO mice. Neurochemical assays revealed that the H1R-KO mice had significantly lower levels of AChE activity in the hippocampus and dopamine turnover in the cerebellum. PMID: 18926883
45. HR1 immunoreactivity was observed on dopaminergic amacrine cells, calretinin-positive ganglion cells and axon bundles in the ganglion cell layer. PMID: 19015005
46. Genetic inactivation of the H1 receptor in the mouse leads to spatial working and reference memory impairments, while having no significant effect on emotional behaviour in the light-dark test. PMID: 19413573
47. Bone marrow-derived mast cell-elaborated histamine inhibits CD4positiveCD25positive regulatory T cell suppressor function by signaling through the histamine H1 receptor. PMID: 19667094
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
數(shù)據(jù)庫鏈接：

KEGG: mmu:15465

STRING: 10090.ENSMUSP00000086383

UniGene: Mm.333327