Recombinant Mouse FUN14 domain-containing protein 1 (Fundc1)

in vitro E.coli expression system

中文名稱：

小鼠Fundc1重組蛋白
貨號：

CSB-CF861601MO
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Fundc1
Uniprot No.：

Q9DB70
別名：

Fundc1; FUN14 domain-containing protein 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-155
氨基酸序列

MASRNPPPQDYESDDESYEVLDLTEYARRHHWWNRVFGHSSGPMVEKYSVATQIVMGGVT GWCAGFLFQKVGKLAATAVGGGFLLLQVASHSGYVQIDWKRVEKDVNKAKRQIKKRANKA APEINNIIEEATDFIKQNIVISSGFVGGFLLGLAS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
基因功能參考文獻：
1. By facilitating Mff-mediated mitochondrial fission and FUNDC1-required mitophagy, NR4A1 disturbed mitochondrial homeostasis, enhanced endothelial apoptosis and provoked microvascular dysfunction in myocardial ischemia reperfusion injury. PMID: 29744594
2. FUNDC1 is required for cardiac ischemia reperfusion injury activated mitophagy. PMID: 28732308
3. hypoxic preconditioning induces FUNDC1-dependent mitophagy in platelets and reduces Ischemia/Reperfusion-induced heart injury, suggesting a new strategy to protect cardiac function and fight cardiovascular diseases. PMID: 28323531
4. FUNDC1 binds to IP3R2 to modulate ER Ca(2+) release into mitochondria and cytosol. Disruption of the FUNDC1 and IP3R2 interaction lowers the levels of Ca(2+) in mitochondria and cytosol, both of which instigate aberrant mitochondrial fission, mitochondrial dysfunction, cardiac dysfunction, and heart failure. PMID: 28942427
5. MicroRNA-137 has a role in inhibiting mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX PMID: 24573672
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亞細胞定位：

Mitochondrion outer membrane; Multi-pass membrane protein.
蛋白家族：

FUN14 family
數據庫鏈接：

KEGG: mmu:72018

STRING: 10090.ENSMUSP00000026016

UniGene: Mm.41558