Recombinant Mouse Cation channel sperm-associated protein 3 (Catsper3)

in vitro E.coli expression system

中文名稱：

Recombinant Mouse Cation channel sperm-associated protein 3(Catsper3)
貨號：

CSB-CF802240MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Catsper3
Uniprot No.：

Q80W99
別名：

Catsper3; Cation channel sperm-associated protein 3; CatSper3
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-395
氨基酸序列

MSQHFHHNPVRVKSGSLFATASEALQARLSKIKRKDKECQAYFRKVIKSTFFQIVMITTV TTNSFLLVLGTNYDIQFEFFRTFEVSELFFVSVYVCEFLMKVYVDPITYWKDGYNILDVI ILIILTIPYLLRKIKGNHSAYLHFADGIQSLRILKLISYSRGIRTLIIAVGETVYTVASV LTLLFLLMFVFAILGFCLFGVTDRGDLENWGNLASAFFTLFSLATVDGWTDLQEELDKRK FTVSRAFTILFILLASFIFLNMFVGVMIMHTEDSMKKFERDLTLERNLAIMEEKQIILKR QQEEVNRLMNTQKSGSMNFIDMVEGFKKTLRHTDPMVLDDFSTSLSFIDIYLVTLDNQDV IVSKLQELYCEIVNVLSLMLEDMPKESSSSLSGLS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.
基因功能參考文獻：
1. Data suggest that Catsper1, Catsper2, Catsper3, and Catsper4 form protein multimer with hypothetical activities of flippase and disulfide isomerase. PMID: 29371110
2. Hydrogen peroxide induced upregulation of catsper3 in brain. PMID: 20586097
3. Catsper3 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer. PMID: 12932298
4. CATSPER3 is a cation-channel protein and has role in acrosome reaction and male fertility PMID: 16107607
5. Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions. PMID: 17344468
6. Data show that spinal cord injury doesn't significantly change the expression of CatSpers 3. PMID: 18607386
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亞細胞定位：

Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.
蛋白家族：

Cation channel sperm-associated (TC 1.A.1.19) family
組織特異性：

Testis-specific.
數(shù)據(jù)庫鏈接：

KEGG: mmu:76856

STRING: 10090.ENSMUSP00000021961

UniGene: Mm.159795