Recombinant Mouse Bombesin receptor subtype-3 (Brs3)

in vitro E.coli expression system

中文名稱：

Recombinant Mouse Bombesin receptor subtype-3(Brs3)
貨號：

CSB-CF002820MO
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Brs3
Uniprot No.：

O54798
別名：

Brs3; Bombesin receptor subtype-3; BRS-3
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-399
氨基酸序列

MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISV GILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGC KVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFAL PEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLI ARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYES YANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDI PLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
基因功能參考文獻：
1. Data suggest that the failure to detect an existing endogenous bombesin-like receptor 3 (BRS-3) ligand in the parabiotic mice could be due to limited cross-circulation and a ligand's short half-life. PMID: 26562312
2. Data show that gastrin-releasing peptide receptor/bombesin receptor subtype-3 positive cells and protein expression in tumors decreased by treatment with RC-3095 or gemcitabine alone or greater in combination. PMID: 24326363
3. Data from knockout mice suggest that Brs3 involvement in regulation of body temperature is via a central mechanism, upstream of sympathetic efferent pathways to stimulate brown adipose tissue. PMID: 24452453
4. This sstudy demonistrated comprehensive mapping of BRS-3 mRNA in the mouse brain and double in situ hybridization was performed to determine whether BRS-3 colocalizes with other neurotransmitters or neuropeptides. PMID: 22911445
5. Data suggest that the bombesin receptor subtype-3 agonist indirectly inhibited orexin neurons through GABAergic input and directly activated orexin neurons. PMID: 20467915
6. BRS-3-deficient mice remained longer in the open arms of the maze. Analyses of risk assessment behavior revealed that BRS-3-deficient mice exhibited increased 'stretched attend posture' behavior in both the L-D box and elevated plus maze tests. PMID: 11803457
7. BRS-3 genes were expressed from embryonic days 13-16 and on multiple postnatal days for lungs PMID: 12959933
8. BRS-3 gene deletion upsets the mechanism by which leptin decreases the expression of MCH-R. PMID: 14988239
9. Hyperphagia is a major factor leading to increased body weight and hyperinsulinemia in BRS-3 KO mice. PMID: 18039774
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
數據庫鏈接：

KEGG: mmu:12209

STRING: 10090.ENSMUSP00000033464

UniGene: Mm.10687