Recombinant Mouse Bax inhibitor 1 (Tmbim6)

in vitro E.coli expression system

中文名稱：

小鼠Tmbim6重組蛋白
貨號：

CSB-CF887505MO
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Tmbim6
Uniprot No.：

Q9D2C7
別名：

Tmbim6; Tegt; Bax inhibitor 1; BI-1; Testis-enhanced gene transcript protein; Transmembrane BAX inhibitor motif-containing protein 6
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-237
氨基酸序列

MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHVVTHFIQAGLLS ALGSLALMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALELCIAVNPSILPTAFMG TAMIFTCFSLSALYARRRSYLFLGGILMSAMSLMLLSSLGNLFFGSIWLFQANLYLGLLV MCGFVLFDTQLIIEKAEHGDKDYIWHCVDLFLDFVTLFRKLMLILAFNEKDKKKEKK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation.
基因功能參考文獻：
1. BI-1 protects against obesity-induced hepatic insulin resistance by regulating CYP2E1 activity and reactive oxygen species production. PMID: 27576594
2. BI-1-mediated enhancement of ApoB secretion regulates hepatic lipid accumulation. PMID: 27297735
3. BI-1 has a major role in the functioning of the adaptive immune system by regulating intracellular Ca(2+) homeostasis in lymphocytes. PMID: 26470731
4. An endogenous protective role of BI-1 under conditions of chronic mild stress. PMID: 24292328
5. Results highlight the regulatory role of BI-1 in idiopathic pulmonary fibrosis. PMID: 24625972
6. BI-1-induced ERK1/2 activation plays an important role in the modulation of intracellular reactive oxygen species generation and apoptotic cell death and may also affect autoimmune response. PMID: 22309999
7. The results reveal BI-1 as a novel autophagy regulator that bridges Ca(2) signaling between ER and mitochondria, reducing cellular oxygen consumption and contributing to cellular resilience in the face of metabolic stress. PMID: 22588718
8. BI-1-mediated enhancement of lysosomal activity regulates P450 2E1 expression and resultant ROS accumulation PMID: 22230367
9. The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. PMID: 22128171
10. highly maintained lysosomal activity may be one of the mechanisms by which BI-1 exerts its regulatory effects on the ER stress response and cell death. PMID: 21586565
11. A critical role of BI-1 as a stress integrator that modulates autophagy levels and other interconnected homeostatic processes. PMID: 21926971
12. BI-1 reduces endoplasmic reticulum (ER) stress and provides protection from acute brain injury via modulation of several ER-associated functions, including unfolded protein response signaling. PMID: 21075086
13. BI-1 may confer affective resiliency in multiple animal models of depression and anhedonia PMID: 21718971
14. NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection. PMID: 20133763
15. Data show that BI-1 increased actin polymerization and cell adhesion through Ca2+ regulation and actin interaction. PMID: 20123969
16. BI-1 is a critical regulator of ER stress responses in the development of obesity-associated insulin resistance PMID: 19996103
17. BI-1 provides endogenous protection of liver and kidney from endoplasmic reticulum stress and ischemia-reperfusion injury. PMID: 16478805
18. BI-1 and Bcl-X(L) operate downstream of or parallel to Bax/Bak PMID: 18299329
19. Discusses cloning of rat testis enhanced gene transcript and identification of its homolog in mouse. PMID: 8012111
20. Discusses cloning of human testis enhanced gene transcript and its conservation in mouse and rat. PMID: 8530040
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亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

BI1 family
組織特異性：

Highly abundant in adult testis.
數據庫鏈接：

KEGG: mmu:110213

STRING: 10090.ENSMUSP00000023749

UniGene: Mm.16769