Recombinant Mouse 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (Agpat3)

in vitro E.coli expression system

中文名稱：

Recombinant Mouse 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma(Agpat3)
貨號：

CSB-CF861543MO
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Agpat3
Uniprot No.：

Q9D517
別名：

Agpat3; Lpaat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; 1-acylglycerol-3-phosphate O-acyltransferase 3; 1-AGP acyltransferase 3; 1-AGPAT 3; Lysophosphatidic acid acyltransferase gamma; LPAAT-gamma
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-376
氨基酸序列

MGLLAYLKTQFVVHLLIGFVFVVSGLIINFTQLCTLALWPISKHLYRRINCRLAYSLWSQ LVMLLEWWSCTECTLFTDQATVDHFGKEHVVVILNHNFEIDFLCGWTMCERFGVLGSSKV LAKRELLCVPLIGWTWYFLEIVFCKRKWEEDRDTVIEGLRRLADYPEYMWFLLYCEGTRF TETKHRISMEVAASKGLPPLKYHLLPRTKGFTTAVQCLRGTVAAIYDVTLNFRGNKNPSL LGILYGKKYEADMCVRRFPLEDIPADETSAAQWLHKLYQEKDALQEMYKQKGVFPGEQFK PARRPWTLLNFLCWATILLSPLFSFVLGVFASGSPLLILTFLGFVGAASFGVRRLIGVTE IEKGSSYGNQELKKKE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA. Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol.
基因功能參考文獻：
1. Data suggest that LPAAT3 is required for producing docosahexaenoic acid- (DHA)-containing phospholipids in various tissues, such as the testes and retina; LPAAT3-knockout mice exhibit severe male infertility with abnormal sperm morphology; lack of LPAAT3 causes drastic reduction of DHA-containing phospholipids in spermatids with excess cytoplasm around the sperm head. PMID: 28578315
2. Data suggest that PL-DHA (docosahexaenoic acid-containing phospholipids) contribute to visual function by maintaining disc shape in photoreceptor cells; PL-DHA disappears from outer segment in LPAAT3-knockout mice; LPAAT3-knockout mice exhibit abnormalities in retinal layers, disordered disc morphology in photoreceptor cells, and impaired visual function. PMID: 28578316
3. The induction of LPAAT3 during germ cell development critically contributes to the accumulation of PUFAs in testicular phospholipids, thereby possibly affecting sperm cell production. PMID: 21968070
4. mAGPAT 1, 2, and 3 mRNA levels increased rapidly in mouse skin after acute permeability barrier disruption PMID: 16150824
亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.
蛋白家族：

1-acyl-sn-glycerol-3-phosphate acyltransferase family
組織特異性：

Widely expressed. Mainly expressed in testis, kidney and liver (at protein level).
數據庫鏈接：

KEGG: mmu:28169

STRING: 10090.ENSMUSP00000001240

UniGene: Mm.141230