Recombinant Epstein-Barr virus Probable membrane protein (BILF1)

in vitro E.coli expression system

中文名稱：

Recombinant Epstein-Barr virus Probable membrane protein (BILF1)
貨號：

CSB-CF360988EFA
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

BILF1
Uniprot No.：

P03208
別名：

BILF1; G-protein coupled receptor BILF1
種屬：

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
蛋白長度：

full length protein
表達區域：

1-312
氨基酸序列

MLSTMAPGSTVGTLVANMTSVNATEDACTKSYSAFLSGMTSLLLVLLILLTLAGILFIIF VRKLVHRMDVWLIALLIELLLWVLGKMIQEFSSTGLCLLTQNMMFLGLMCSVWTHLGMAL EKTLALFSRTPKRTSHRNVCLYLMGVFCLVLLLIIILLITMGPDANLNRGPNMCREGPTK GMHTAVQGLKAGCYLLAAVLIVLLTVIIIWKLLRTKFGRKPRLICNVTFTGLICAFSWFM LSLPLLFLGEAGSLGFDCTESLVARYYPGPAACLALLLIILYAWSFSHFMDSLKNQVTVT ARYFRRVPSQST
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Constitutively active G protein-coupled receptor that plays a role in the modulation of host immunity. As a consequence of its constitutive activity, mediates host CXCR4 inhibition. Enhances degradation of host major histocompatibility complex class I antigens via lysosomes. Targets also newly synthesized MHC-I/peptide complexes en route to the host cell surface. Inhibits the host EIF2AK2/PKR phosphorylation.
基因功能參考文獻：
1. These data indicate that whilst BNLF2a interferes with antigen presentation with diminishing efficiency as lytic cycle progresses (IE>E>>L), interference by BILF1 increases with progression through lytic cycle (IE PMID: 25144360
2. BILF1 cytoplasmic C-terminal tail is required for reducing surface HLA class I expression since it is expressed early in the viral lytic cycle targeting a broad range of (HLA) class I molecules, including multiple HLA-A and -B types and HLA-E. PMID: 23315076
3. This study therefore extends our initial observations on BILF1 to show that this immunoevasin can target MHC-I antigen presentation via both the exocytic and endocytic trafficking pathways. PMID: 21123379
4. Study show the formation of hetero-oligomeric complexes between this viral BILF1 and human CXCR4. BILF1 impaired CXCL12 binding to CXCR4 and, consequently, also CXCL12-induced signaling. PMID: 20622011
5. Inverse agonists for BIL1 could inhibit cell transformation and be relevant therapeutic candidate. PMID: 20543866
6. BILF1 physically interacts with various host chemokine receptors on the cell surface of human cells. PMID: 18823943
7. BILF1 reduced the levels of MHC class I at the cell surface and inhibited CD8(+) T cell recognition of endogenous target antigens PMID: 19119421
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亞細胞定位：

Host cell membrane; Multi-pass membrane protein.
蛋白家族：

Epstein-Barr virus BILF1 protein family
數據庫鏈接：

KEGG: vg:3783707