Recombinant Bovine Dipeptidyl peptidase 4 (DPP4)

in vitro E.coli expression system

中文名稱：

牛DPP4重組蛋白
貨號：

CSB-CF007139BO
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

DPP4
Uniprot No.：

P81425
別名：

DPP4; CD26; Dipeptidyl peptidase 4; Activation molecule 3; ACT3; Adenosine deaminase complexing protein; ADCP-I; Dipeptidyl peptidase IV; DPP IV; T-cell activation antigen CD26; WC10; CD antigen CD26
種屬：

Bos taurus (Bovine)
蛋白長度：

full length protein
表達區域：

1-765
氨基酸序列

MKTPWKVLLGLLAIAALVTVITVPVVLLTKGNDASTDSRRTYTLADYLKNTFRMKFYNLRWVSDHEYLYKQENNILLFNAEYGNSSIFLENSTFDEFGHSINDYSVSPDRQYILFEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSSVGHKLAYVWNNDIYVKNEPNSPSQRITWTGKKDVIYNGITDWVYEEEVFSAYSALWWSPNSTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVKIPYPKAGAVNPTIKFFVVNISSLSPNINATSQQIVPPGSVLIGDHYLCDVTWVTEERISLQWLRRIQNYSIMDICDYDRSTGRWISSVGRQHIEISTTGWVGRFRPAEPHFTSDGNSFYKIISNEEGYKHICHFQTDKRNCTFITKGAWEVIGIEALTSDYLYYISNEYKGMPGARNLYKIQLNDYTKVTCLSCELNPDRCQYYSVSFSQEAKYYQLRCSGPGLPLYTLHNSNNDKELRVLENNSDLDQVLQDVQMPSKKLDFIHLHGTKFWYQMILPPHFDKSKKYPLLLEVYAGPCSQKADAIFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWEYYDSVYTERYMGLPTPEDNLDSYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDAGVDFQSMWYTDEDHGIASSTAHQHIYTHMSHFLKQCFSLL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
基因功能參考文獻：
1. Results describe a proline-rich cytokine from neurosecretory granules that represents a new natural substrate for Dipeptidyl Peptidase IV (DPPIV). PMID: 20838887
2. This and other dipeptidyl peptidases can be isolated from bovine testes. PMID: 18508455
3. Data demonstrate that dipeptidyl peptidase II can form a complex with adenosine deaminase, but with one order of magnitude higher dissociation constant than that of DPPIV. PMID: 18774942
亞細胞定位：

[Dipeptidyl peptidase 4 soluble form]: Secreted.; Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Cell projection, invadopodium membrane; Single-pass type II membrane protein. Cell projection, lamellipodium membrane; Single-pass type II membrane protein. Cell junction. Membrane raft.
蛋白家族：

Peptidase S9B family, DPPIV subfamily
組織特異性：

Intestinal epithelium, dendritic cells and several immune system tissues.
數據庫鏈接：

KEGG: bta:281122

STRING: 9913.ENSBTAP00000020379

UniGene: Bt.8282