CHOK1/Mouse CCR8 Stable Cell Line
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貨號：CSB-SC004847MO
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規格：1 vial contains approximately 5x106 cells in 1 ml
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價格：￥30000
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活性：
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Untransfected CHO-K1 cells (green line) and transfected Mouse CCR8 CHO-K1 Stable cells (red line) were stained with anti-Mouse CD198-PE antibody (2μg/1*106cells) and analyzed with flow cytometry.
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其他：
產品詳情
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Uniprot No.：
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生長類型：Adherent
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抗性：Puromycin
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培養基：F-12K + 10% FBS + 6μg/mL Puromycin
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別名：CCR8
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蛋白標簽：Tag-Free
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保存緩沖液：35% FBS + 55% F-12K + 10% DMSO
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應用范圍：Binding assay by FACS and cell based ELISA.
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儲存條件：Frozen in liquid nitrogen or stored at -80°C
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關產品
靶點詳情
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功能：Receptor for the CCL1/SCY1/TCA-3 chemokine.
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基因功能參考文獻：
- CCR8 negatively regulates migration of cutaneous dendritic cells from the skin to the draining lymph nodes in contact hypersensitivity by keeping these cells in the skin. PMID: 25344933
- Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages. PMID: 24714157
- A sustained donor Treg presence is critical for their beneficial properties, and that their survival depends on CCR8 and donor but not host CD11c(+) Aantigen presenting cells. PMID: 23798714
- Expression of CCR-8 in microglia was upregulated in the presence of CCL-1. PMID: 23747724
- C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
- Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. PMID: 22031018
- a key regulator of Th2 cell skin recruitment during IL-5-mediated allergic inflammation PMID: 21217759
- mediates increased responsiveness of murine eosinophils to TCA-3 PMID: 12050188
- Data from three different models plus an in vivo blocking study clearly show that the Th2 cell-mediated pathological response to ovalbumin-induced allergic airway inflammation is not critically CCR8-dependent. PMID: 12574386
- sulfation at specific positions of the N-terminal domain of mouse CCR8 is critical for its biological activity, whereas glycosylation has a minor influence PMID: 14736884
- IL-10 production correlates with CCR8 ligand (CCL1) expression and the appearance of CCR8+ cells in granulomatous lungs and is required for full expression of the T helper type 2 cell response to parasite antigens. PMID: 15699124
- CCR8 may have a negative impact on host defense during septic peritonitis, providing a new paradigm for the role of CCR8 in innate immunity. PMID: 16384913
- CCR8 ligands are allotropic, binding to distinct sites within CCR8 PMID: 17023422
- CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
- Ccr8 has a pivotal role in the progression of experimental fungal asthma. PMID: 17321573
- Mast cell-derived CCR8- and CCL1-expressing CD4-positive effector T lymphocytes play an essential role in orchestrating lung mucosal inflammatory responses. PMID: 17641040
- Results suggest that CCR8 plays a significant role in the pathogenesis of experimental autoimmune encephalomyelitis and probalby of multiple sclerosis. PMID: 17850582
- CCR8/CCL1 interaction may play a role in type 1 diabetes through macrophage recruitment and activation PMID: 17947648
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：G-protein coupled receptor 1 family
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組織特異性：Expressed in thymus.
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數據庫鏈接：
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