Recombinant Xenopus laevis Forkhead box protein C1-A (foxc1-a)

中文名稱：

有爪蟾蜍foxc1-a重組蛋白
貨號：

CSB-YP886110XBE
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

有爪蟾蜍foxc1-a重組蛋白
貨號：

CSB-EP886110XBE
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

有爪蟾蜍foxc1-a重組蛋白
貨號：

CSB-EP886110XBE-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

有爪蟾蜍foxc1-a重組蛋白
貨號：

CSB-BP886110XBE
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

有爪蟾蜍foxc1-a重組蛋白
貨號：

CSB-MP886110XBE
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

foxc1-a
Uniprot No.：

Q9PVZ3
別名：

foxc1-a; foxc1; Forkhead box protein C1-A; FoxC1; Fork head domain-related protein 11; XFD-11
種屬：

Xenopus laevis (African clawed frog)
蛋白長度：

full length protein
表達區(qū)域：

1-492
氨基酸序列

MQARYSVSSP NSLGVVPYLS GEQSYYRAAA AAAAAGGGYT GMAAPMSMYS HPAHEQYQAG MARAYGPYTP QPQPKDMVKP PYSYIALITM AIQNAPDKKI TLNGIYQFIM ERFPFYRDNK QGWQNSIRHN LSLNECFVKV PRDDKKPGKG SYWTLDPDSY NMFENGSFLR RRRRFKKKDV SKDATKEDKE RLLKEHHGSQ SAAAQQQRQQ QQSQAQAEQD SNSQPVRIQD IKTENGTSSP PQSMSPALSA VPKIESPDSS SSMSSGSPHS IPSNRSMSLE AAESHHPHHQ QHSQGFSVDN IMTSLRGSPQ GSAELPSPLI SSSRTGIAPS LSLSYSPGQG SIYSSPCSQG TSSGGGAGTY HCNMQAMSLY SGDRSGHLTP ANTPAATTVE ETLPDYSIST TSAQSHGNQE HPHQGRLPSW YLNQTGELGH LAGATYPGQQ QNFHSVREMF ESQRLALNSS PVNGNSSCQM SFPPSQSLYR TSGAFVYDCS KF
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion. Involved in chemokine-induced endothelial cell migration. Plays a role in epidermal keratinocyte terminal differentiation. Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage. Plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Plays a role at the gastrula stage for expression of several mesodermal and endodermal genes. At the late neurula stage, regulates expression of adhesion genes to maintain cell adhesion in the mesodermal germ layer.
基因功能參考文獻：
1. at late neurula to early tailbud stage, FoxC1 depletion causes down-regulation of adhesion molecules, EP & E cadherin, & members of the Ephrin/EphR signaling families in the mesoderm germ layer resulting in loss of adhesion & apoptosis of mesodermal cells PMID: 17705306
亞細胞定位：

Nucleus.
組織特異性：

In gastrulae, expressed in ventral and lateral but not dorsal mesoderm. In neurulae, expressed in the posterior mesoderm except for the dorsal midline, and also at the lateral border of the neural plate and within anterior neuroectoderm. From tailbud stag
數(shù)據(jù)庫鏈接：

KEGG: xla:394280

UniGene: Xl.180