Recombinant Xenopus laevis F-box only protein 43 (fbxo43), partial

中文名稱：

有爪蟾蜍fbxo43重組蛋白
貨號：

CSB-YP805219XBE
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

有爪蟾蜍fbxo43重組蛋白
貨號：

CSB-EP805219XBE
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

有爪蟾蜍fbxo43重組蛋白
貨號：

CSB-EP805219XBE-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

有爪蟾蜍fbxo43重組蛋白
貨號：

CSB-BP805219XBE
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

有爪蟾蜍fbxo43重組蛋白
貨號：

CSB-MP805219XBE
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

fbxo43
Uniprot No.：

Q8AXF4
別名：

fbxo43; emi2; erp1; fbx26F-box only protein 43; Early mitotic inhibitor 2; Emi1-related protein 1; F-box protein 26; Xerp1
種屬：

Xenopus laevis (African clawed frog)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required to prevent anaphase onset in cytostatic factor-arrested oocytes. Inhibits the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase and prevents cyclin degradation. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
基因功能參考文獻：
1. the APC/C-inhibitory activity of XErp1 (also known as Emi2) was essential for early divisions in Xenopus embryos. PMID: 23019610
2. Emi2 stability and activity are dynamically regulated by Emi2-bound multiple kinases and PP2A phosphatase. PMID: 21871841
3. Erp1/Emi2 is essential for the meiosis I to meiosis II transition in Xenopus oocytes. PMID: 17141208
4. Emi2 directs meiosis II-specific cytostatic factor cell cycle arrest. PMID: 17361107
5. Emi2/XErp1 is the critical cytostatic factor component directly responsible for anaphase-promoting complex/cyclosome inhibition during CSF arrest. PMID: 17361104
6. These findings provide a novel mechanism of APC/C inhibition wherein the final step of ubiquitin transfer is targeted and raise the interesting possibility that APC/C is inhibited by Emi2 in a catalytic manner. PMID: 20534816
7. Data show that Emi2 binds the anaphase-promoting complex/cyclosome via the C-terminal tail. PMID: 20089832
8. review mechanism of action and mode of regulation of Emi2, CSF function, and the general principles of APC/C regulation and control of protein function by MAPK pathways [review] PMID: 18946022
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數據庫鏈接：

KEGG: xla:100101275

UniGene: Xl.76218