Recombinant Transitional endoplasmic reticulum ATPase homolog 2 (cdc-48.2), partial

中文名稱：

Recombinant Transitional endoplasmic reticulum ATPase homolog 2(cdc-48.2) ,partial
貨號：

CSB-YP346206CXY
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Transitional endoplasmic reticulum ATPase homolog 2(cdc-48.2) ,partial
貨號：

CSB-EP346206CXY
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Transitional endoplasmic reticulum ATPase homolog 2(cdc-48.2) ,partial
貨號：

CSB-EP346206CXY-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Transitional endoplasmic reticulum ATPase homolog 2(cdc-48.2) ,partial
貨號：

CSB-BP346206CXY
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Transitional endoplasmic reticulum ATPase homolog 2(cdc-48.2) ,partial
貨號：

CSB-MP346206CXY
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

cdc-48.2
Uniprot No.：

P54812
別名：

cdc-48.2; C41C4.8; Transitional endoplasmic reticulum ATPase homolog 2; EC 3.6.4.6; Cell division cycle-related protein 48.2; p97/CDC48 homolog 2
種屬：

Caenorhabditis elegans
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. Together with udf-2 and chn-1, regulates myosin assembly in body wall muscles by targeting myosin chaperone unc-45 for proteasomal degradation. During oocyte meiosis and together with cdc-48.1, required for chromosome condensation at the diakinesis phase in prophase I and for progression of metaphase I. During the first embryonic cell division, regulates DNA replication and thus chromosome segregation and decondensation, and nuclear envelope re-assembly. In S phase and in association with ufd-1, npl-4.1 and/or npl-4.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5. Regulates ubxn-3 nuclear localization during S phase. During the first embryonic cell divisions and together with cdc-48.1, regulates the re-assembly of the nuclear envelope after mitosis possibly by inactivating kinase air-2, a component of the chromosomal passenger complex (CPC).
基因功能參考文獻：
1. data reveal an essential pathway that regulates reformation of the nucleus after mitosis and defines ubiquitin-dependent protein extraction as a common mechanism of Cdc48/p97 activity also during nucleus formation PMID: 18097415
2. ATX-3 interacts with both VCP/p97 worm homologs, CDC-48.1 and CDC-48.2 and the interaction domains were mapped. PMID: 19545544
亞細胞定位：

Cytoplasm.
蛋白家族：

AAA ATPase family, CDC48 subfamily
組織特異性：

Expressed in body wall muscles.
數據庫鏈接：

KEGG: cel:CELE_C41C4.8

STRING: 6239.C41C4.8.3

UniGene: Cel.7497