Recombinant Thermotoga maritima DNA integrity scanning protein DisA (disA)

中文名稱：

海棲熱袍菌disA重組蛋白
貨號：

CSB-YP894400TNJ
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

海棲熱袍菌disA重組蛋白
貨號：

CSB-EP894400TNJ
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

海棲熱袍菌disA重組蛋白
貨號：

CSB-EP894400TNJ-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

海棲熱袍菌disA重組蛋白
貨號：

CSB-BP894400TNJ
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

海棲熱袍菌disA重組蛋白
貨號：

CSB-MP894400TNJ
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

disA
Uniprot No.：

Q9WY43
別名：

disA; TM_0200; DNA integrity scanning protein DisA; Cyclic di-AMP synthase; c-di-AMP synthase; Diadenylate cyclase; EC 2.7.7.85
種屬：

Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
蛋白長度：

full length protein
表達區域：

1-357
氨基酸序列

MGVKSLVPQE LIEKIKLISP GTELRKALDD IINANFGALI FLVDDPKKYE DVIQGGFWLD TDFSAEKLYE LSKMDGAIVL SEDITKIYYA NVHLVPDPTI PTGETGTRHR TAERLAKQTG KVVIAVSRRR NIISLYYKNY KYVVNQVDFL ISKVTQAIST LEKYKDNFNK LLSELEVLEL ENRVTLADVV RTLAKGFELL RIVEEIRPYI VELGEEGRLA RMQLRELTED VDDLLVLLIM DYSSEEVEEE TAQNILQDFI TRREPSPISI SRVLGYDVQQ AAQLDDVLVS ARGYRLLKTV ARIPLSIGYN VVRMFKTLDQ ISKASVEDLK KVEGIGEKRA RAISESISSL KHRKTSE
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.; Has diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. This rate-limiting step is the accessibility of the active site; mutating the possible exit tunnel (residues 128-130) increases product 2-fold despite Arg-130 being important for ATP-binding. Does not convert GTP to c-di-GMP.
基因功能參考文獻：
1. Mutations of selected active-site residues (Asp75, Arg130, Thr107, Thr111) led to significantly decreased diadenylate cyclase activity of DisA.[DisA] PMID: 26014055
蛋白家族：

DisA family
數據庫鏈接：

KEGG: tma:TM0200

STRING: 243274.TM0200