Recombinant Schizosaccharomyces pombe Serine/threonine-protein kinase tel1 (tel1), partial

中文名稱：

龐貝裂殖酵母tel1重組蛋白
貨號：

CSB-YP525594SXV
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

龐貝裂殖酵母tel1重組蛋白
貨號：

CSB-EP525594SXV
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

龐貝裂殖酵母tel1重組蛋白
貨號：

CSB-EP525594SXV-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

龐貝裂殖酵母tel1重組蛋白
貨號：

CSB-BP525594SXV
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

龐貝裂殖酵母tel1重組蛋白
貨號：

CSB-MP525594SXV
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

tel1
Uniprot No.：

O74630
別名：

tel1; SPCC23B6.03cSerine/threonine-protein kinase tel1; EC 2.7.11.1; ATM homolog; DNA-damage checkpoint kinase tel1; Telomere length regulation protein 1
種屬：

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Undirectly involved in the phosphorylation of rad32 which is necessary for its telomere function. Required for the control of telomere length and genome stability.
基因功能參考文獻：
1. The structure suggests that ataxia-telangiectasia mutated protein (ATM/Tel1) dimer interface and the consecutive HEAT repeats inhibit the binding of kinase substrates and regulators by steric hindrance. PMID: 27229179
2. It is a DNA damage sensor kinases and plays a roll in telomere maintenance. PMID: 25675824
3. Tel1(ATM)/Rad3(ATR)-dependent Ccq1 Thr93 phosphorylation is a critical regulator of telomere maintenance in fission yeast. PMID: 22101932
4. The N-terminus of Nbs1 contributes to the recruitment of Rad3(ATR)-Rad26(ATRIP) to telomeres. PMID: 20140190
5. Recombination-based telomere maintenance is dependent on Tel1 and Rap1 and inhibited by telomerase, Taz1, and Ku. PMID: 18160711
6. Tel1 and Rad3 are required for both protection of telomeres against recombination and promotion of telomerase recruitment. PMID: 19714219
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亞細胞定位：

Nucleus. Chromosome, telomere.
蛋白家族：

PI3/PI4-kinase family, ATM subfamily
數據庫鏈接：

KEGG: spo:SPCC23B6.03c

STRING: 4896.SPCC23B6.03c.1