Recombinant Schizosaccharomyces pombe Negative regulator of ofd1 (nro1)

中文名稱：

龐貝裂殖酵母nro1重組蛋白
貨號：

CSB-YP892388SXV
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

龐貝裂殖酵母nro1重組蛋白
貨號：

CSB-EP892388SXV
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

龐貝裂殖酵母nro1重組蛋白
貨號：

CSB-EP892388SXV-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

龐貝裂殖酵母nro1重組蛋白
貨號：

CSB-BP892388SXV
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

龐貝裂殖酵母nro1重組蛋白
貨號：

CSB-MP892388SXV
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

nro1
Uniprot No.：

Q9USJ7
別名：

nro1; SPCC4B3.07; Negative regulator of ofd1
種屬：

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
蛋白長度：

full length protein
表達區(qū)域：

1-393
氨基酸序列

MIGRRPQGLR AAASLKKQQQ LEKQKQEASY ELSGNSSPSK ENGSENVDNG EMEDETMLVY TEEDNISQLW GLYEMSREKL ENDDIDASVS LVFGTIHEAD RILRNTEDIS TLPKDFHAAY SSALLAVSEL FEIAQKRLKE TNTEESYIDA AIERAQLGLD APGNESRLFL ALARAYLEKV RVLVWRHDNE ESLANIPVTQ LVNPYIEKAI QYLRPLAQDS TEYFDALTPD SLRPLYILSS YLFQFGDQFS EAFLLDVCSI ITALWLKSVV DPNTPAYYKL IAQEAVLNNY TTFAEYYMDL LDNSESNVDD LINKASSWLN NSVDTWNVIY TLDKSPERLL KLADIKMDLA QIVQDEASQD NYLKEACNAI KEAQGSGVEL SPDYVEFVEA YSA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for correct translation termination. Positive regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. Acts also as a direct inhibitor of ofd1. Functions probably by inhibiting the ability of the ofd1 to accelerate Sre1N degradation in absence of oxygen.
基因功能參考文獻：
1. Nro1 unexpectedly adopts a Tetratrico Peptide Repeat (TPR) fold, a motif often responsible for protein or peptide binding. PMID: 21610214
2. Studies indicate that the Nro1 NTD binds Ofd1CTDD and stabilizes Sre1N. PMID: 21481773
3. we identify Nro1 (SPCC4B3.07) as a positive regulator of Sre1N stability and a direct inhibitor of Ofd1. PMID: 19158663
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

ETT1 family
數(shù)據庫鏈接：

KEGG: spo:SPCC4B3.07

STRING: 4896.SPCC4B3.07.1