Recombinant Saccharomyces cerevisiae Thioredoxin-1 (TRX1)

中文名稱：

釀酒酵母TRX1重組蛋白
貨號：

CSB-YP325248SVG
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

釀酒酵母TRX1重組蛋白
貨號：

CSB-EP325248SVG
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

釀酒酵母TRX1重組蛋白
貨號：

CSB-EP325248SVG-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

釀酒酵母TRX1重組蛋白
貨號：

CSB-BP325248SVG
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

釀酒酵母TRX1重組蛋白
貨號：

CSB-MP325248SVG
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TRX1
Uniprot No.：

P22217
別名：

TRX1; TRX2; YLR043C; Thioredoxin-1; Thioredoxin I; TR-I; Thioredoxin-2
種屬：

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-103
氨基酸序列

VTQFKTASE FDSAIAQDKL VVVDFYATWC GPCKMIAPMI EKFSEQYPQA DFYKLDVDEL GDVAQKNEVS AMPTLLLFKN GKEVAKVVGA NPAAIKQAIA ANA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl-hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism.
基因功能參考文獻：
1. NMR spectroscopic studies of yeast TRX1 provide insights into the mechanism for the closing of the water cavity. PMID: 26482062
2. TRX1 is required to maintain the IMS small Tim proteins in reduced forms and facilitate their mitochondrial import PMID: 22878414
3. Results show that an oxidized sulfiredoxin under disulfide state is formed between the catalytic Cys(84) and Cys(48), and this oxidized is reduced selectively by thioredoxin. PMID: 19801666
4. The cytosolic form of thioredoxin Trx1 has been cloned, expressed, purified and crystallized. PMID: 18391437
5. Human wt p53 expression in yeast leads to gene repression of thioredoxin (TRX1/2), a highly conserved multifunctional antioxidative and antiapoptotic protein family. PMID: 19054132
6. X-ray diffraction analysis of glutathionylated Trx1 C33S mutant from yeast PMID: 19153453
7. study solved the crystal structures of oxidized Trx1 and glutathionylated Trx1Cys33Ser mutant at 1.76 and 1.80 A, respectively; kinetic studies proved that Met35Arg mutation could alter the apparent K(m) and V(max) values of the reaction PMID: 19362171
8. Trx1 and Trx2 are essential for the nuclear accumulation of Msn2/4 and Maf1. PMID: 19581440
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亞細胞定位：

Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
蛋白家族：

Thioredoxin family
數據庫鏈接：

KEGG: sce:YLR043C

STRING: 4932.YLR043C