Recombinant Saccharomyces cerevisiae Dynein heavy chain, cytoplasmic (DYN1), partial

中文名稱：

釀酒酵母DYN1重組蛋白
貨號：

CSB-YP330521SVG
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

釀酒酵母DYN1重組蛋白
貨號：

CSB-EP330521SVG
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

釀酒酵母DYN1重組蛋白
貨號：

CSB-EP330521SVG-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

釀酒酵母DYN1重組蛋白
貨號：

CSB-BP330521SVG
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

釀酒酵母DYN1重組蛋白
貨號：

CSB-MP330521SVG
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

DYN1
Uniprot No.：

P36022
別名：

DYN1; DHC1; YKR054CDynein heavy chain; cytoplasmic; Dynein heavy chain; cytosolic; DYHC
種屬：

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.
基因功能參考文獻：
1. Interplay among dynein, dynactin, and the stability of the microtubule substrate creates a mechanism that regulates accurate spindle positioning. PMID: 28572117
2. Lis1 (Pac1) regulates dynein by sterically blocking its mechanochemical cycle. PMID: 25380312
3. DYN1 is engaged in bidirectional helical motility around microtubules in the process of cargo transport. PMID: 25069614
4. Study reports X-ray and electron microscopy structures of yeast dynein, DYN1 bound to different ATP analogs, which collectively provide insight into the roles of dynein's two major ATPase sites, AAA1 and AAA3, in the conformational change mechanism. PMID: 25417161
5. The authors find that dynein has a highly variable stepping pattern that is distinct from all other processive cytoskeletal motors, which use 'hand-over-hand' mechanisms. PMID: 22231401
6. study presents a 6 angstrom crystal structure of a functional dimer of two ~300-kilodalton motor domains of cytoplasmic dynein PMID: 21330489
7. A model for how dynein's two motor domains coordinate their activities during normal processive motility. PMID: 18045537
8. the nucleotide binding state at AAA3 and AAA4 of the heavy chain of cytoplasmic dynein can allosterically modulate microtubule binding affinity and affect dynein processivity and force production PMID: 18650442
9. Results suggest that dynein and Cin8 cooperate in anaphase midzone organization and influence microtubule dynamics, thus enabling progression through the slow phase of anaphase B. PMID: 19099194
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亞細胞定位：

Cytoplasm, cytoskeleton. Note=Concentrates at motile dots in the cytoplasm corresponding to the plus ends of cytoplasmic microtubules.
蛋白家族：

Dynein heavy chain family
數據庫鏈接：

KEGG: sce:YKR054C

STRING: 4932.YKR054C