Recombinant Rat Transient receptor potential cation channel subfamily V member 4 (Trpv4), partial
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中文名稱：大鼠Trpv4重組蛋白
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貨號：CSB-EP863666RA-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：Trpv4; Vroac; Transient receptor potential cation channel subfamily V member 4; TrpV4; Osm-9-like TRP channel 4; OTRPC4; Vanilloid receptor-related osmotically-activated channel; VR-OAC
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種屬：Rattus norvegicus (Rat)
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蛋白長度：Partial
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by heat, low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Together with PKD2, forms mechano- and thermosensitive channels in cilium. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes. Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes. Together with AQP5, controls regulatory volume decrease in salivary epithelial cells. Required for normal development and maintenance of bone and cartilage. In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus.
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基因功能參考文獻：
- HO-2 and TRPV4 were also confirmed to form a complex in SFO neurons. PMID: 27436489
- TRPV4 channels play an important role in the regulation of the adrenergic vascular tone of pulmonary artery smooth muscle cells, but TRPV4 activation mechanism(s) and signaling pathways remain unclear. PMID: 29537229
- This study was undertaken to investigate the mechanism underlying TRPV4-mediated myocardial ischemia/reperfusion injury. PMID: 28542130
- In conclusion, TRPV4 differently regulates insulin mRNA expression in INS-1E cells via ERK1/2 and NO-dependent mechanisms. PMID: 28359774
- These data indicate that TRPV4 is functionally expressed in vestibular ganglion (VG) neurons as an ion channel and that TRPV4 likely participates in VG neurons for vestibular neurotransmission as an osmoreceptor and/or mechanoreceptor. PMID: 27705979
- irisin may induce endothelium-dependent vasodilation by activating Ca(2+) influx into endothelial cells via TRPV4 channels PMID: 29097199
- findings demonstrate that FHH rat cerebral arterial myocytes express mRNA transcript and translated protein for TRPV4 channel and display TRPV4-like single-channel cationic current activity that was stretch-sensitive and activation of which increased the open state probability of KCa single-channel current in these arterial myocytes PMID: 28472069
- Results indicate that osmosensitive transient receptor potential channel 4 protein (TRPV4) controls hypotonic-induced responses in synoviocytes. PMID: 28274876
- TRPV4 is expressed in mouse and rat gastric epithelium and contributes to ATP release and gastric emptying. PMID: 27350729
- these results support the link between TRPV4 and p38 and their intermediary role for neuropathic pain in rats with chronic compression of the dorsal root ganglion. PMID: 27366753
- Data suggested that the impairment of TRPV4-mediated Ca2+ signaling in epithelial cells contributed to the age-related decrease of flow-induced vessel dilation in mesenteric arteries. PMID: 26947561
- TRPV4 channel activity modulates uterine contractility and might represent a therapeutic target to address preterm labor. PMID: 26702092
- Overexpression and altered cellular distribution of TRPV4 observed in focal cortical dysplasia suggest that TRPV4 may potentially contribute to the epileptogenesis of focal cortical dysplasia PMID: 26842013
- Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol PMID: 26294342
- Aquaporin-mediated fast swelling kinetics play a key role in cell volume regulation (together with TRPV4) and calcium signaling in astrocytes PMID: 26413835
- hyperglycaemia and diabetes reduce the molecular and functional expression of TRPV4 channels in retinal microvascular endothelial cells. PMID: 26047504
- We conclude that flow-induced increases in Cai are mediated primarily by TRPV4 in the rat mTAL. PMID: 25980432
- TRPV4 and calcium-activated potassium channels functionally couple as osmosensors in the paraventricular nucleus PMID: 25421636
- TRPV4 could inhibit hepatic stellate cells apoptosis partially by regulating autophagy-dependent AKT signaling pathway activation. PMID: 25600591
- TRPV1/4 channels are potent therapeutic targets for site-specific vasodilation in the kidney PMID: 25069877
- Data suggest that age-related increases in transient receptor potential vanilloid type 4 (TRPV4) expression in the brain and spinal cord may provide information for investigating the pathogenesis of age-related neurodegenerative diseases. PMID: 24917364
- We examined the role of TRPV4 channels in the development of high-amplitude spontaneous Ca(2) oscillations in astrocyte endfeet and the inversion of neurovascular coupling after subarachnoid hemorrhage. PMID: 25366609
- activation of TRPV4 channels mediates flow-induced NO production in thick ascending limb PMID: 24966090
- TRPV4, TRPC1, and TRPP2 contribute to the ion permeation pore of the channels PMID: 25114176
- This study provided the first evidence for TRPC1 and TRPV4 channels as potential contributors to mechanosensation in the atrial volume receptors. PMID: 24631674
- Demonstrate increased TRPV4 expression in the urothelium following stress and that TRPV4 blockade ameliorates stress-induced bladder dysfunction. PMID: 24965792
- Results show that TRPV4 activation in the intestinal epithelium caused epithelial hyperpermeability in response to NSAID-induced arachidonic acid metabolites and contributed to NSAID-induced intestinal damage. PMID: 24789205
- ASMC proliferation in response to TRPV4 activity. PMID: 24392954
- The results of the present study suggest that endothelial TRPV4 channels are present in the endothelium of the rat pulmonary artery and their activation causes endothelium-dependent relaxation involving NO and EDHF. PMID: 24075884
- our results provide the first evidence that glial cell-expressed TRPV4 is a potential key factor responsible for infrasound-induced neuronal impairment PMID: 24002225
- These data show, therefore, a particular role of IL-17 in mechanical hyperalgesia, and they suggest that this effect is linked to an activation and upregulation of TRPV4. PMID: 23147107
- TRPV4 mediates Ca(2+) influx and substance P release in dorsal root ganglion. PMID: 22762361
- The mechanosensitive ion channel, TRPV4, regulates cardiac fibroblast differentiation to myofibroblasts by integrating signals from TGF-beta1 and mechanical factors. PMID: 23142541
- the functional status of TRPV4, which underlies mechanosensitive Ca(2 ) signaling in collecting duct cells, inversely correlates with renal cystogenesis in autosomal recessive polycystic kidney disease. PMID: 23411787
- Coimmunoprecipitation experiments of transfected cells revealed that rat TRPV4 and tubulin beta 5 associated together in a complex. PMID: 22309793
- TRPV4 protein was predominantly located in the nucleus of cultured neonatal myocytes PMID: 23027348
- Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling PMID: 23288842
- Trpv4 expression in female Wistar rats varied with postnatal age, tissue (urothelium, detrusor, or whole bladder), and duration (4-h, 48-h, or chronic) of cyclophosphamide-induced cystitis. PMID: 22865090
- show that TRPV4 channels are involved in ischemia-induced calcium entry in reactive astrocytes and thus, might participate in the pathogenic mechanisms of astroglial reactivity following ischemic insult PMID: 22761937
- Relevance of the TRPV4-RyR2 signaling pathway under hypoxic conditions that may lead to pulmonary hypertension. PMID: 22962011
- TRPV1 is implicated in rat pulmonary arterial smooth muscle cells migration. PMID: 22820913
- It was shown that both retinal and vestibular ganglion cells can be stimulated reproducibly by lasers and that neuronal responses are driven through transient receptor potential vanilloid 4 channels. PMID: 22442563
- In this rat model of inflammation, TRPV-4 is expressed and functional in trigeminal ganglion neurons and synovial cells PMID: 22184014
- TRPV4 was the only member of the TRPV and TRPM subfamilies upregulated in PAs of chronic hypoxic rats. PMID: 22207590
- Activation of TRPV4 in the bladder, probably urothelium, facilitates the micturition reflex by activation of the mechanosensitive, Cap-insensitive C-fibers of the primary bladder afferents in rats. PMID: 22038643
- aberrant TRPV4 activity may lead to some types of pathology of sensory and motor nerves PMID: 22187434
- activation of TRPV4 within the meninges produces afferent nociceptive signaling from the head that may contribute to migraine headache. PMID: 22049072
- our data suggested that NF-kappaB could be involved in TRPV4-NO pathway in CCD-induced thermal hyperalgesia. PMID: 21356247
- Pharmacological Trpv4 activation enhanced cerebral arteriogenesis, pinpointing Trpv4 as a possible candidate for the development of new therapeutic concepts. PMID: 21316269
- Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. PMID: 20956320
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亞細胞定位：Cell membrane. Apical cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Cell projection, cilium.
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蛋白家族：Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV4 sub-subfamily
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組織特異性：Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia.
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