Recombinant Rat Thyroid hormone receptor alpha (Thra)

中文名稱：

大鼠Thra重組蛋白
貨號：

CSB-YP023510RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Thra重組蛋白
貨號：

CSB-EP023510RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Thra重組蛋白
貨號：

CSB-EP023510RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Thra重組蛋白
貨號：

CSB-BP023510RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Thra重組蛋白
貨號：

CSB-MP023510RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Thra
Uniprot No.：

P63059
別名：

Thra; C-erba-alpha; Nr1a1; Thyroid hormone receptor alpha; Nuclear receptor subfamily 1 group A member 1; c-erbA-1; c-erbA-alpha
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-492
氨基酸序列

MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCPLKSSMS GYIPSYLDKD EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM IRSLQQRPEP TPEEWDLIHV ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ QLLGMHVVQG PQVRQLEQQF GEAGSLRGPV LQHQSPKSPQ QRLLELLHRS GILHSRAVCG EDDSSEASSL SSSSSDEDTE VFEDLAGKAA SP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
基因功能參考文獻：
1. This study demonstrated that reduction of the thyroid hormone receptor alfa (Tralpha1)mRNA expression in hippocampus of thyroidectomized Wistar rats. PMID: 26861177
2. The roles of nitric oxide synthase and TRalph1 in hyperthyroid and hypothyroid rats are reported. PMID: 25726374
3. down-regulated in hepatocellular carcinoma PMID: 25156012
4. role for TRalpha1 in the regulation of hypothalamic TRH mRNA expression, whereas TRbeta plays a dominant role in pituitary and liver thyroid hormone metabolism. PMID: 22985455
5. conjugation of SUMO to TR has a TR-isoform preference and is important for T3-dependent gene induction and repression. PMID: 22930759
6. Data show that acute T3-limiting effect on reperfusion injury is mediated, at least in part, via TRalpha1 receptor. PMID: 21442236
7. Data show that thyroid hormone induced rat aorta smooth muscle cell proliferation by up-regulating NOX1 in a TRalpha1-dependent manner. PMID: 20414976
8. Acute myocardial infarction in diabetic rats results in TH receptor down-regulation with important physiological consequences PMID: 20730619
9. Progression to congestive heart failure after myocardial infarction is associated with suppressed expression of TR alpha 1 and results in tissue hypothyroidism. PMID: 20560106
10. thyroid hormone and thyroid hormone receptor TRalpha regulate expression of the Na+/H+ exchanger PMID: 12039959
11. Diurnal changes in liver TR alpha 1 and TR alpha 2 are controlled by the biological clock in the SCN but not via changes in the daily rhythm of food intake PMID: 14657007
12. role for both the proteosome degradation pathway and altered mRNA stability in T3-induced decrease of nuclear TRalpha1 in the cardiomyocyte PMID: 15498821
13. These results implicate protein kinase C-alpha as a regulator of thyroid receptor-alpha1 function and suggest that nuclear localization of protein kinase C-alpha may control transcription of the TR alpha gene, and consequently, affect cardiac phenotype. PMID: 16155104
14. TRalpha2 is a single stranded RNA binding protein; the RNA binding domain localizes to a 41 amino acid region immediately distal to second zinc finger; phosphorylated TRalpha2 is primarily cytoplasmic & unphosphorylated TRalpha2 is primarily nuclear PMID: 16356627
15. TRalpha isoforms may directly regulate T(3) responses at mtDNA in the heart PMID: 16730242
16. In outer hair cells, TH enhanced the expression of the prestin gene through TRbeta. Simultaneously Kcnq4 expression was activated in the same cells by derepression of TRalpha1. PMID: 16803873
17. Cardiac dysfunction which occurs at late stages after acute myocardial infarction is associated with increased expression of TR alpha 1 receptor and lower circulating tri-iodothyronine levels. PMID: 17389455
18. TR-dependent regulatory cascades are controlled differently in organs with a complementary tissue expression pattern and in those with cellular co-expression of the TRalpha and TRbeta genes. PMID: 17496154
19. TRalpha1 mRNA upregulated in hyperthyroid myocardium and downregulated in hypothyroid myocardium. TRalpha2 mRNA downregulated in hyperthyroid myocardium and upregulated in hypothyroid myocardium. PMID: 18000305
20. The data show that the expression of thyroid hormone receptor alpha 1 and its mRNA levels were increased by the hypothyroid state. PMID: 18299881
21. Over-expression of thyroid hormone receptor alpha1 may lead to fetal cardiac phenotype in the absence of thyroid hormone availability. PMID: 18622044
22. TR alpha 1 and TR beta 1 divergently regulate cardiac pacing activity. TH-induced positive chronotropic effects are likely to be mediated by TR alpha 1 through enhanced expression of I(f) pacemaker current and its underlying genes. PMID: 19629520
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亞細胞定位：

Nucleus.; [Isoform Alpha-2]: Cytoplasm. Nucleus.
蛋白家族：

Nuclear hormone receptor family, NR1 subfamily
數據庫鏈接：

KEGG: rno:81812

STRING: 10116.ENSRNOP00000012340

UniGene: Rn.11307