Recombinant Rat Tachykinin-3 (Tac3)

中文名稱：

大鼠Tac3重組蛋白
貨號：

CSB-YP023063RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Tac3重組蛋白
貨號：

CSB-EP023063RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Tac3重組蛋白
貨號：

CSB-EP023063RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Tac3重組蛋白
貨號：

CSB-BP023063RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Tac3重組蛋白
貨號：

CSB-MP023063RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Tac3
Uniprot No.：

P08435
別名：

Tac3; Nknb; Tac2; Tachykinin-3 [Cleaved into: Neurokinin-B; NKB; Neuromedin-K)]
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Cytoplasmic domain
表達區域：

82-91
氨基酸序列

DMHDFFVGL M
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function.
基因功能參考文獻：
1. The expressions of each mRNA (Kiss1, Tac3, and Pdyn) and each peptide (kisspeptin, NKB, and DynA) in the ARC significantly decreased in Zucker fatty rats compared with Zucker lean rats PMID: 29203206
2. data suggest that endogenous NeuroKinin B-Neurokinin 3 Receptor signalling plays a role in controlling the timing of puberty. PMID: 24863620
3. NKB agonist stimulates FSH secretion in a strikingly developmental-dependent manner PMID: 25490143
4. The divergent regulation of kisspeptin and NKB peptide contents in the arcuate nucleus as a function of sex and steroid milieu enlarge our understanding on how these neuropeptides are posttranscriptionally regulated in KNDy neurons. PMID: 25051440
5. Data suggest few hypothalamic genes are sexually dimorphic during postnatal development; only Tac2/neurokinin B, Esr1 (estrogen receptor 1), and Kiss1 (KiSS-1 metastasis-suppressor) are dimorphic (i.e., higher in females) in developing preoptic area. PMID: 23034157
6. Data suggest that the earlier accelerated GnRH pulse generator frequency and advanced puberty with obesogenic diets might be associated with premature up-regulation of kisspeptin and NKB signaling in the hypothalamus of the female rat. PMID: 22733968
7. Neurokinin B-neurokinin 3 receptor signaling plays a role in pubertal maturation; its alterations may contribute to pubertal disorders linked to metabolic stress and negative energy balance. PMID: 22396413
8. absence of a strong ARH Kiss1/NKB projection to the preoptic area suggests regulation of GnRH by this population occurs primarily at the ME level via local projection PMID: 21029216
9. Data suggest that NKB/NK3R signaling in kisspeptin+ neurons in the arcuate nucleus plays a pivotal role in control of GnRH/LH secretion. NKB and NK3R mRNAs are widely expressed in the central forebrain. PMID: 21045176
10. although the expression patterns of Tac2 and NKB are similar in rats and mice, noteworthy differences exist. Our results have important implications for the interpretation of behavioral results concerning the NKB/NK3 system in these species. PMID: 16160861
11. Gosha-jinki-gan reduces neurokinin A/B, substance P, TRPV1 and P2X3 receptors associated with C fiber activation induced by acetic acid in rat urinary bladder. PMID: 18551569
12. An extract (THC-002) of Ba-Wei-Die-Huang-Wan inhibits expression of tachykinins, and P2X3 and TRPV1 receptors, and inhibits ATP-induced detrusor overactivity in spontaneously hypertensive rats. PMID: 19283865
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亞細胞定位：

Secreted.
蛋白家族：

Tachykinin family
數據庫鏈接：

KEGG: rno:29191

STRING: 10116.ENSRNOP00000005679

UniGene: Rn.9708