Recombinant Rat Solute carrier family 40 member 1 (Slc40a1), partial

中文名稱：

大鼠Slc40a1重組蛋白
貨號：

CSB-YP852868RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Slc40a1重組蛋白
貨號：

CSB-EP852868RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Slc40a1重組蛋白
貨號：

CSB-EP852868RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Slc40a1重組蛋白
貨號：

CSB-BP852868RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Slc40a1重組蛋白
貨號：

CSB-MP852868RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc40a1
Uniprot No.：

Q923U9
別名：

Slc40a1; Fpn1; Fpt1; Solute carrier family 40 member 1; CAR1; Cell adhesion regulator; Ferroportin-1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Major iron transporter that plays a key role in balancing cellular and systemic iron levels. Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes. When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma.
基因功能參考文獻：
1. Data suggest that expression of ferroportin in intestinal mucosa can be regulated by dietary factors; here, partially hydrolyzed guar gum up-regulates expression of ferroportin in cecum mucosa in growing rats being treated for iron deficiency anemia with this probiotic; intestinal absorption of dietary iron appears to be up-regulated, as well. PMID: 28273797
2. The significantly increased FPN1 level in small intestine facilitates digestive iron absorption, which maintains the serum iron concentration at a near-normal level to meet the increase of iron requirements PMID: 26788496
3. In ischemic rats, Fpn1 expression in the cerebral cortex and hippocampus was decreased. PMID: 19766498
4. Data suggest that expression of ferroportin (Slc40a1) in intestinal mucosa can be regulated by dietary factors; here, expression of ferroportin in mucosa of duodenum is down-regulated by prebiotic supplement, oligofructose, in iron-deficiency anemia. PMID: 25745840
5. Atp7a knockdown in IEC-6 cells enhanced transepithelial iron flux via a novel molecular mechanism involving transcriptional induction of Fpn1 gene expression. PMID: 24174620
6. The role for intracellular hepcidin generated in the substantia nigra is particularly relevant to restrict iron release by down-regulation FPN1 expression PMID: 22659129
7. Ferroportin-1 is a 'nuclear'-negative acute-phase protein in rat liver. PMID: 22469696
8. Decreased intracellular levels of iron in preneoplastic foci might be attributed to increased iron export from the cells, driven by upregulation of ferroportin (Fpn1. PMID: 21785164
9. Iron absorption during suckling is largely refractory to changes in expression of the systemic iron regulator hepcidin, and this in turn reflects limited expression of Fpn1 protein in the small intestine. PMID: 21570398
10. With the increases of iron levels in diet, the levels of serum iron, serum ferretin, and transferrin saturation were gradually increased, and the expression of ferroprotin mRNA expression level in duodenum was decreased. PMID: 18839536
11. contributes to iron accumulation in a cell model of Parkinson's disease PMID: 19913091
12. the finding of a novel mutation (V162del) in ferroportin1 in an Australian family with autosomal dominant hemochromatosis; the mutation disrupts the function of the ferroportin1 protein, leading to impaired iron homeostasis and iron overload PMID: 12091366
13. direct evidence for the existence of ferroportin1 protein in the rat brain. age has a significant effect on the expression of ferroportin1 protein in the cortex, hippocampus, striatum and substantia nigra of the rat brain. PMID: 12401946
14. Ferroportin may function as a modulator of DMT1 activity and play a role in Fe(III) uptake, possibly by affecting the number or affinity of citrate binding sites. PMID: 15114483
15. Ferroprotin-1 gene expression is up-regulated by treatment with the pro-inflammatory cytokine IL-1beta in rat C6 cells, taken as a glial cellular model. PMID: 15172111
16. Findings suggest that ferroportin may transport iron into the mucous granule where it would be lost during discharge of mucous. PMID: 15944915
17. Ferroportin 1 might have a role in heart iron homeostasis. PMID: 17383861
18. FPN1 was decreased in normal peritoneal exudate macrophages after treatment with rHuEpo in vitro; hepcidin may play a major, causative role in the change of FPN1 synthesis PMID: 18189270
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Ferroportin (FP) (TC 2.A.100) family, SLC40A subfamily
數據庫鏈接：

KEGG: rno:170840

STRING: 10116.ENSRNOP00000005228

UniGene: Rn.15324