Recombinant Rat Sodium/iodide cotransporter (Slc5a5), partial

中文名稱：

大鼠Slc5a5重組蛋白
貨號：

CSB-YP720383RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Slc5a5重組蛋白
貨號：

CSB-EP720383RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Slc5a5重組蛋白
貨號：

CSB-EP720383RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Slc5a5重組蛋白
貨號：

CSB-BP720383RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Slc5a5重組蛋白
貨號：

CSB-MP720383RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc5a5
Uniprot No.：

Q63008
別名：

Slc5a5; Nis; Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Mediates iodide uptake in the thyroid gland.
基因功能參考文獻：
1. Nis expression is controlled by Txn/Ape1 through a TSH/selenium-dependent mechanism. PMID: 26650895
2. excess iodide transcriptionally represses NIS gene expression through the impairment of Pax8 and p65 transcriptional activity. PMID: 26872612
3. Report sodium binding date for NIS, where transporter activity is electrogenic, with a 2:1 Na(+)/I(-) transport stoichiometry. PMID: 26009546
4. Although the affinity of NIS for I- is low, it increases when Na+ is bound. NIS takes advantage of the extracellular Na+ concentration and the pronounced increase in its own affinity for I- and for the second Na+ elicited by binding of the first. PMID: 24888603
5. It is feasible to use lentiviral vectors to deliver sodium iodide symporter (NIS) gene for the non-invasive monitoring of bone marrowderived mesenchymal stem cell transplantation and survival in the infarcted myocardium in vivo. PMID: 25319483
6. sodium/iodide symporter expression is inhibited by iodide excess in a process involving the PI3K/Akt signaling pathway PMID: 24424051
7. Molecular imaging of luciferase signal and sodium-iodide symporter imaging may be useful for in vivo optimization of bioenergetics in transplanted cells. PMID: 23255420
8. Overexpression of p38beta or Rac1 significantly enhanced (1.9- and 3.9-fold, respectively), the tRA-stimulated NIS expression in MCF-7 cells. PMID: 22157753
9. This study found that KT5823 decreases iodide uptake within 0.5 h of treatment in trans-retinoic acid and hydrocortisone-treated MCF-7 breast cancer cells, but increases iodide uptake in thyroid cells. PMID: 21209020
10. A physical interaction was observed between the NF-kappaB p65 subunit and paired box 8 (Pax8), which appears to be responsible for the synergic effect displayed by these transcription factors on NIS gene transcription. PMID: 20667985
11. Data show for the first time that iodide regulates sodium-iodide symporter mRNA expression at the posttranscriptional level, providing a new mechanism by which iodide exerts its autoregulatory effect on thyroid. PMID: 20107044
12. PI3K is involved in the IGF-I inhibition of TSH-induced sodium/iodide symporter gene expression PMID: 11818505
13. an uncharged amino acid residue with a small side chain at position 395 is required for Na(+)/I(-) symporter activity PMID: 12145342
14. sodium/iodide symporter gene is repressed by TGFbeta, which is regulated by interacting Pax8 and Smad3 PMID: 14623893
15. The high degree of homology in the 5'-flanking region between mouse and rat NIS suggests that mNIS and rNIS share similar mechanisms for transcriptional regulation in the thyroid. PMID: 15009910
16. Data show that tumor cells expressing the thyroidal sodium iodide symporter (NIS) retain iodide longer than thyroid cells due to a combination of slow efflux and reuptake. PMID: 15522214
17. water transport across the membrane can be explained by cotransport of water in the membrane proteins and that intracellular unstirred layers effects are minute PMID: 16322051
18. A significant proportion of human cholangiocarcinomas expresses membrane sodium iodide symporter, which may permit radioiodine therapy. Our data also suggest that (131)I acts on a crucial target for liver cancer development. PMID: 17408651
19. MEK inhibition restores NIS protein levels and NIS-mediated radioiodide uptake activity in RET/PTC oncogene-transformed thyroid cells. PMID: 17639055
20. that NIS protein levels and functional activity could be modulated by phosphorylation through distinct mechanisms. PMID: 17913707
21. Gene transfer permits sequential real-time detection and quantification of reporter gene expression in the transplanted heart with micro-SPECT/CT imaging. PMID: 18165779
22. The Na+/I- symporter mediates active iodide uptake in the intestine. PMID: 19052257
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Sodium:solute symporter (SSF) (TC 2.A.21) family
數據庫鏈接：

KEGG: rno:114613

STRING: 10116.ENSRNOP00000025577

UniGene: Rn.10505