Recombinant Rat Sodium-coupled neutral amino acid transporter 1 (Slc38a1), partial

中文名稱：

大鼠Slc38a1重組蛋白
貨號：

CSB-YP881352RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Slc38a1重組蛋白
貨號：

CSB-EP881352RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Slc38a1重組蛋白
貨號：

CSB-EP881352RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Slc38a1重組蛋白
貨號：

CSB-BP881352RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Slc38a1重組蛋白
貨號：

CSB-MP881352RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc38a1
Uniprot No.：

Q9JM15
別名：

Slc38a1; Ata1; Glnt; Sa2; Sat1; Snat1; Sodium-coupled neutral amino acid transporter 1; Amino acid transporter A1; rATA1; Glutamine transporter; N-system amino acid transporter 2; Solute carrier family 38 member 1; System A amino acid transporter 1; System A transporter 2; System N amino acid transporter 1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.
基因功能參考文獻：
1. Overexpression of X-box binding protein-1 led to a marked increase in luciferase activity in P19 cells transfected with the Slc38a1 reporter plasmid. These results suggest that theanine accelerates cellular proliferation and subsequent neuronal specification through a mechanism relevant to upregulation of Slc38a1 gene in undifferentiated neural progenitor cells PMID: 25957749
2. Oxidative stress increases SNAT1 expression and stimulates cysteine uptake in rat cardiomyocytes. PMID: 20602128
3. SNAT1/SAT1 is the amino acid transporter system member that plays a critical role in dynamically modulating inhibition in response to metabolic demands. PMID: 20492358
4. distribution of SNAT1 in central nervous system neurons and characterization of its transport properties PMID: 12684517
5. A high-capacity imino acid carrier localized at the small intestinal luminal membrane that transports nutrients and amino acids and imino acids. PMID: 15521011
6. Immunohistochemistry demonstrates the presence of SNAT1 within the placental labyrinth and within fetal endothelium. PMID: 16023720
7. SNAT1 protein expression decreased in the liver and intestine shortly after birth and as the rat matured; SNAT1 expression was constant throughout development in the lungs and kidney and increased in the heart from prenatal day 19 to postnatal day 2 PMID: 16200463
8. GlnT expression is upregulated by cyclic AMP/protein kinase A signals for subsequent exacerbation of the vulnerability to oxidative stress in astrocytes. PMID: 17323379
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain.
蛋白家族：

Amino acid/polyamine transporter 2 family
組織特異性：

Specifically expressed in brain with the highest levels in cerebellum and thalamus (at protein level). Expressed in glutamatergic, GABAergic and a subset of dopaminergic neurons of the substantia nigra and cholinergic motoneurons (at protein level). Also
數據庫鏈接：

KEGG: rno:170567

STRING: 10116.ENSRNOP00000008138

UniGene: Rn.162022