Recombinant Rat Sodium bicarbonate cotransporter 3 (Slc4a7), partial

中文名稱：

大鼠Slc4a7重組蛋白
貨號：

CSB-YP865644RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Slc4a7重組蛋白
貨號：

CSB-EP865644RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Slc4a7重組蛋白
貨號：

CSB-EP865644RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Slc4a7重組蛋白
貨號：

CSB-BP865644RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Slc4a7重組蛋白
貨號：

CSB-MP865644RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc4a7
Uniprot No.：

Q9R1N3
別名：

Slc4a7; Nbc; Nbc2; Nbc3; Nbcn1; Sodium bicarbonate cotransporter 3; Electroneutral sodium bicarbonate cotransporter 1; NBC-like protein; Solute carrier family 4 member 7
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.
基因功能參考文獻：
1. The finding of a genotypic influence on SLC4A7 expression and pHi regulation in vascular smooth muscle cells provides an insight into the molecular mechanism underlying the association of variation at the SLC4A7 locus with blood pressure PMID: 28087731
2. A binding site for calcineurin A beta was found to reside within splice cassette II of NBCn1. PMID: 23382378
3. Current-voltage relationships showed a positive and nearly linear relationship between NH(4)Cl-mediated current and voltage, which was markedly reduced by NBCn1. PMID: 21571816
4. The electroneutral sodium bicarbonate co-transporter SLC4A7 localizes in mitochondria and suppresses the ischaemia-induced activation of the mitochondrial pathway of apoptosis in coronary endothelial cells. PMID: 20962104
5. In acidic conditions, kidney medullary thick ascending DIDS-sensitive bicarbonate extrusion is inactivated, while NBCn1 is upregulated to stimulate ammonium transport. PMID: 20591978
6. It was concluded that NBCn1 in neurons is upregulated by chronic acid loads, and this upregulation is associated with glutamate excitotoxicity. PMID: 20147654
7. NBCn1 is a basolateral Na(+)-HCO(3)(-) cotransporter of inner medullulary collecting duct cells and is differentially regulated in these and medullary thick ascending limb. PMID: 15075186
8. Slc4a7 activity is enhanced during development of cardiac hypertrophy. PMID: 17416604
9. We conclude that NBCn1 has a dynamic upregulation in low pH(o) and Mg(2+) depletion. NBCn1 is not required for acidic protection, but increases cytotoxicity in Mg(2+)-free conditions. PMID: 19170751
10. We conclude that the primary function of cassette II is to reduce NBCn1 protein expression PMID: 19638364
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亞細胞定位：

Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell projection, stereocilium. Note=Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells.
蛋白家族：

Anion exchanger (TC 2.A.31) family
組織特異性：

Expressed in aorta, ventricles, atrium, mesenteric artery, kidney, spleen, duodenum, jejunum, ileum, colon, lung, trachea, gastric fundus and pylorus, cerebrum, cerebellum, pancreas, liver, parotid gland, and epididymis. Expressed in the inner ear by coch
數據庫鏈接：

KEGG: rno:117955

STRING: 10116.ENSRNOP00000008759

UniGene: Rn.26856