Recombinant Rat Small kinetochore-associated protein (Skap)

中文名稱：

大鼠Knstrn重組蛋白
貨號：

CSB-YP715255RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Knstrn重組蛋白
貨號：

CSB-EP715255RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Knstrn重組蛋白
貨號：

CSB-EP715255RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Knstrn重組蛋白
貨號：

CSB-BP715255RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Knstrn重組蛋白
貨號：

CSB-MP715255RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Knstrn
Uniprot No.：

Q6AXN6
別名：

Knstrn; Skap; Traf4af1; Small kinetochore-associated protein; SKAP; Kinetochore-localized astrin-binding protein; Kinastrin; Kinetochore-localized astrin/SPAG5-binding protein; TRAF4-associated factor 1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-312
氨基酸序列

MATHKAEAQE TDFRTTGPPT DLEQCPFPPS SRKFPFESVA ADSTEGWAVA AEHHLKRSGE DGGWEQPASG VEPSRPTTMA SSKTVCDAQP HSMPSCGLSA DTQTRATSKL PVKSKDAEML RHLHTGGLEP DVTKVTKPRR ENGQGKAAET ASRRNIRSSY KPLSKQKPEE DLKDKNELLE AVNKQLHQKL TETQGELKDL TQKVELLEKF QDNCLAILES KGLNSGQETQ ESKQEPSTDP TDSMLLLETL KDELKLFNET AKKQMEELQA LKVKLKLKEK ERIQFLEQQT LGKDEASDFT IILEEMEQLL EM
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division.
基因功能參考文獻：
1. These results indicate that Astrin is required for normal mitotic progression in immature Sertoli cells and that the most severe type of testicullar dysplasia in hgn/hgn rats is caused by mitotic cell death of immature Sertoli cells due to lack of Astrin. PMID: 28351621
亞細胞定位：

Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.
數據庫鏈接：

KEGG: rno:311325

STRING: 10116.ENSRNOP00000012454

UniGene: Rn.20235