Recombinant Rat RalA-binding protein 1 (Ralbp1)

中文名稱：

大鼠Ralbp1重組蛋白
貨號：

CSB-YP737095RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Ralbp1重組蛋白
貨號：

CSB-EP737095RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Ralbp1重組蛋白
貨號：

CSB-EP737095RA-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Ralbp1重組蛋白
貨號：

CSB-BP737095RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Ralbp1重組蛋白
貨號：

CSB-MP737095RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ralbp1
Uniprot No.：

Q62796
別名：

Ralbp1; RalA-binding protein 1; RalBP1; Cytocentrin; Dinitrophenyl S-glutathione ATPase; DNP-SG ATPase; Ral-interacting protein 1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

2-647
氨基酸序列

TECFLPPTS SPSEHRRAEH GSGLTRTPSS EEISPTKFPE LYRTGEPSPP HDILHEPPDI VSDDEKDHGK KKGKFKKKEK RTEGYVAFQE DSSGDEAESP SKMKRSKGIH VFKKPSFSKK KEKDFKIKEK PKEEKHKEEK HKEEKHKEKK CKDFTAADVV KQWKEKKKKK KPTQEPEVPQ TDAPSLRPIF GAPFADAVER TMMYDGIRLP AVFRECVDYM EKHGMKCEGI YRVSGIKSKV DELKAAYDRE ESPNLEEYEP NTVASLLKQY LRDLPENLLT KELMPRFEEA CGRTTEVEKV QEFQRLLREL PEYNHLLLSW LIVHMDHVIA KELETKMNIQ NISIVLSPTV QISNRVLYVL FTHVQELFGT VLLKQVTRPL RWSNMATMPT LPETQAGIKE EIRRQEFLLN CLHRDLQGGI KDFSKEERLW EVQRILTALK RKLREAKRQE CETKIAQEIA SLSKEDVSKE ETNENEEVIN ILLAQENEIL TEQEELLAME QFLRRQIASE KEEIDRLRAE IAEIQSRQHG RSETEEYSSD SESESEDEEE LQIILEDLQR QNEELEIKNN HLNQAVHEER EAIVELRVQL RLLQMLRAKS EQQLQEEEEP ERRGGTGPLP CEGVLEVRAA KEQAKPSPSK DRKETPI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity. As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L.; Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance.
基因功能參考文獻：
1. Phosphorylation of RIP1 is the essential molecular mechanism of necroptosis. PMID: 28252651
2. subarachnoid hemorrhage led to the upregulation of RIP1, RIP3, phosphorylated DRP1 and NLRP3 inflammasome PMID: 28579326
3. These results demonstrated that indole-3-carbinol could induce apoptosis of hepatic stellate cells through RIP1 K63 de-ubiquitination by upregulating deubiquitinase CYLD. PMID: 28395284
4. We propose that NMDAR activation brings RalBP1 close to PSD-95 to promote the interaction of RalBP1-associated endocytic proteins with PSD-95-associated AMPARs. PMID: 19823667
亞細胞定位：

Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Mitochondrion.
組織特異性：

Ubiquitously expressed.
數(shù)據(jù)庫鏈接：

KEGG: rno:84014

STRING: 10116.ENSRNOP00000033120

UniGene: Rn.7107