Recombinant Rat Putative E3 ubiquitin-protein ligase SH3RF2 (Sh3rf2)

中文名稱：

大鼠Sh3rf2重組蛋白
貨號：

CSB-YP675459RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Sh3rf2重組蛋白
貨號：

CSB-EP675459RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Sh3rf2重組蛋白
貨號：

CSB-EP675459RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Sh3rf2重組蛋白
貨號：

CSB-BP675459RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Sh3rf2重組蛋白
貨號：

CSB-MP675459RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Sh3rf2
Uniprot No.：

Q498M5
別名：

Sh3rf2; Posh3; Posher; Ppp1r39; Rnf158; E3 ubiquitin-protein ligase SH3RF2; EC 2.3.2.27; POSH-eliminating RING protein; Protein phosphatase 1 regulatory subunit 39; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; SH3 domain-containing RING finger protein 2
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-735
氨基酸序列

MDDLTLLDLL ECPVCFEKLD VTAKVLPCQH TFCKPCLQRI FKAHKELRCP ECRTLVFCSI EALPANLLLV RLLDGVRSGH NSWRGGSFRR PRILTLQDNR KAKSSPRSLQ ASPFRLGPTV RIHMDGVPRA KALCNYRGKN PGDLKFNKGD VILLQRQLDE NWYQGEINGV SGFFPASSVE VIKQLPQPPP LCRALYNFDL RDKDKSENQD CLTFLKDDVI TVISRVDENW AEGKLGDKVG IFPILFVEPN LSARHLLEKS KGHQLSRTKH LSLMSSPSRG KATNTSTLRK SPGSRRKGSG QFAMTTALNT LNRMVHSPEG HQMVEISTPV LISSTSPSML TQHGDRADFP ASSAGQVSTS HPAPASPGHS TAMVSVPSSQ QHLSTNMFVA LHTYSAQGPE ELDLKKGEGI RVLGKNQDGW LRGVSLVTGR TGIFPSDYVI PVFSSTARKT SSFPDSRHPT VCTTWALSTS SVSSQGSFSE GDPRQSGPFR SVFVPTAVNP PRSTSGPGTS GQGSLRKVRS SMRKNGSLQR PVQSGIPTFM VGSLRCSPAM VIRPQKFQFY QPQGMTPSPT PIMVEIGSKS ISTGEPALTC INRGGKTRTH SAGNSIIMEG KETPIKSEPP PKPPASAPPS ILVKPENSKN GIEKQVKTVR FQNYSPPPTK HSASGPTSGK HEQPATLKGS QPEAVSSEGE MTILFAHRSG CHSGQQTDLR RKSAFSKTTP PVSTASVSQT LFPSK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation. Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity.
基因功能參考文獻：
1. These results indicate that POSH2 may regulate JNK activation and consequent apoptosis under conditions of increased expression. PMID: 17762203
亞細胞定位：

Nucleus.
蛋白家族：

SH3RF family
數據庫鏈接：

KEGG: rno:307472

UniGene: Rn.211767