Recombinant Rat Protein-lysine 6-oxidase (Lox)

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中文名稱：

大鼠Lox重組蛋白
貨號(hào)：

CSB-EP013038RA
說明書：

MSDS Datasheet
規(guī)格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Lox
Uniprot No.：

P16636
別名：

LoxProtein-lysine 6-oxidase; EC 1.4.3.13; Lysyl oxidase) [Cleaved into: Protein-lysine 6-oxidase; long form; Protein-lysine 6-oxidase; short form]
種屬：

Rattus norvegicus (Rat)
蛋白長(zhǎng)度：

Full Length of Mature Protein
來源：

E.coli
分子量：

33.0kDa
表達(dá)區(qū)域：

163-411aa
氨基酸序列

DDPYNPYKYSDDNPYYNYYDTYERPRSGSRHRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 6xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture.
基因功能參考文獻(xiàn)：
1. data suggest a detrimental role for the chronic increase of cardiac LOX expression and activity in the transition from compensated remodeling to decompensated failure. PMID: 28668305
2. Together, these findings suggest that bone fragility in DM2 is initiated in the matrix phase and that the LOX family may play a critical part in the pathogenesis of DM2 mediated bone fragility. PMID: 29146187
3. Here we show that orthotopic implantation of rat prostate AT-1 tumour cells increased LOX and LOXLs mRNA expressions in the tumour and in the surrounding non-malignant prostate tissue PMID: 26804196
4. The reduction of leptin levels by BAPN in vivo and the ability of this compound to inhibit leptin-induced profibrotic mediators and ROS production in cardiac and vascular cells suggest that interactions between leptin and LOX regulate downstream events responsible for myocardial and vascular fibrosis in obesity. PMID: 26780438
5. LOX can promote the progress of epithelial-to-mesenchymal transition in a rat model of pulmonary fibrosis. PMID: 26670953
6. In transgenic mice expressing rat LOX in wild-type megakaryocytes and platelets, higher affinity of Pf4-Lox(tg/tg) platelets to the collagen sequence GFOGER implies that the collagen receptor integrin alpha2beta1 is affected by LOX. PMID: 26755713
7. Silenced lysyl oxidase expression results the growth of C3H10T1/2 cells by 50%, and blocked osteoblast differentiation. PMID: 24971753
8. Decreased lox expression in diaphragmatic development and lung branching morphogenesis may contribute to the diaphragmatic defect and impaired airway formation in the nitrofen-induced congenital diaphragmatic hernia model. PMID: 25111273
9. Results indicate that polyphenols bind to monomeric tropoelastin and enhance coacervation, aid in crosslinking of elastin by increasing lysyl oxidase (LOX) synthesis, and by blocking MMP-2 activity. PMID: 24440697
10. Study supports a novel mechanism of n-acetylcysteine alleviating idiopathic pulmonary fibrosis by inhibition of LOX activity in a rat model. Time course of LOX activity during bleomycin-induced pulmonary fibrosis was also examined. PMID: 23006535
11. These results suggest that in an indirect co-culture system, pelvic ligament fibroblasts with mechanical stretch stimulation can promote bone mesenchymal stem cell differentiation, reflecting in the increased expression of elastin, LOX, and Fibulin-5. PMID: 22205540
12. These findings indicate that TNF-alpha stimulated LOX expression may play an important role in progressive cardiac fibrosis. PMID: 21893029
13. In cardiac fibroblasts, Rac1 GTPase mediates upregulation of fibronectin via LOX and CTGF. PMID: 21215756
14. The data presented herein regarding chromatin remodeling indirectly support the hypothesis that LOX binds to histone H1 in vivo. PMID: 20888776
15. LOX were overexpressed in late stages of intimal hyperplasia in the allografts PMID: 20606470
16. Suggest that uric acid increases fibronectin synthesis both in vivo and in vitro via urate transporters through upregulation of lysyl oxidase expression. PMID: 20484295
17. lysyl oxidase propeptide contains both N- and O-linked carbohydrates; its structure is a mostly disordered protein PMID: 20192271
18. Data indicate that lysyl oxidase propeptide (LOX-PP) inhibits terminal mineralization in primary calvaria osteoblast cultures when added at early stages of differentiation, with no effects seen when present at later stages. PMID: 20048148
19. a PKC-MEK-MAPK-dependent pathway is critical to the enhanced expression of the LO gene PMID: 11968017
20. findings indicate control of lysyl oxidase at endocrine, paracrine, and autocrine levels within the ovary and suggest coordinated regulation of ovarian extracellular matrix during follicular development PMID: 12488341
21. comparison and aa sequence alignment of human and rat lysyl oxidase and lysyl oxidase-like gene (LOXL1); role in formation and repair of ECM elastin and collagen PMID: 12577300
22. Beta-catenin transformation pathway is activated by lysyl oxidase down-regulation. PMID: 12686140
23. The results showed that LOX was expressed in the choroid plexus, blood vessel walls, brain matrix, and neurons of normal rat. PMID: 14741400
24. Upregulation by cigarette smoke condensate(CSC) of cellular thiols may play an important role in the downregulation of lysyl oxidase and subsequently destabilization of the lung ECM in CS-induced emphysema. PMID: 15509664
25. Downregulation of LO is linked with upregulation of other Cu-binding proteins and with alteration in Cu homeostasis in the cadmium resistant lung fibroblasts. PMID: 17584760
26. These novel data suggest that LOX-PP may provide a feedback control mechanism that serves to inhibit properties associated with the development of vascular pathology. PMID: 18060869
27. spatial and temporal expression of LOX and LOXL1 during growth and aging in the aorta and specific roles for LOX and LOXL1 in the synthesis and remodeling of elastic and collagen fibers PMID: 18803461
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亞細(xì)胞定位：

Secreted. Secreted, extracellular space.
蛋白家族：

Lysyl oxidase family
組織特異性：

Aorta and lung.
數(shù)據(jù)庫(kù)鏈接：

KEGG: rno:24914

STRING: 10116.ENSRNOP00000065314

UniGene: Rn.11372