Recombinant Rat Pleckstrin homology domain-containing family O member 1 (Plekho1)

中文名稱：

大鼠Plekho1重組蛋白
貨號(hào)：

CSB-YP704705RA
說明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

大鼠Plekho1重組蛋白
貨號(hào)：

CSB-EP704705RA
說明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

大鼠Plekho1重組蛋白
貨號(hào)：

CSB-EP704705RA-B
說明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Plekho1重組蛋白
貨號(hào)：

CSB-BP704705RA
說明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

大鼠Plekho1重組蛋白
貨號(hào)：

CSB-MP704705RA
說明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Plekho1
Uniprot No.：

Q5BJM5
別名：

Plekho1; Pleckstrin homology domain-containing family O member 1; PH domain-containing family O member 1
種屬：

Rattus norvegicus (Rat)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-408
氨基酸序列

MKKSGSGKRG PPDGNHQSVA PEKVGWVRKF CGKGIFREIW KNRYVVLKGD QLYVSEKEVK DEKNSQEVFD LSDYEKCEEL RKSKSRSKKN HSKFTLARCR QPGTTAPNLI FLAVSPEEKE SWINALSSAI TRAKNRILDE VTVEEDSYLA HPTRDRAKIQ HSRRPPTRGH LMAVASTSTS DGMLTLDLIQ EEDPSPEEPA SCAESFRVDL DKSVAQLAGS RRRADSDRIR PSSHRASSLS RPWERPDKGA PYTPQALKKL PSTEKSRCAS LEEILSQRDT APAHPLHLQA EESPAPVPSQ PGQLSRIQDL VARKLEKTQE LLAEVQGLGD GKWKAKDPPR SPPDSQSEQL LLETERLLGE ASSNWSQAKR VLQEVRELRD LYRQMDLQTP DSHLRQTSQH SQYRKSLM
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
基因功能參考文獻(xiàn)：
1. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging. PMID: 28083909
亞細(xì)胞定位：

Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm.
數(shù)據(jù)庫(kù)鏈接：

KEGG: rno:310674

STRING: 10116.ENSRNOP00000028747

UniGene: Rn.21037