Recombinant Rat Plasma cell-induced resident endoplasmic reticulum protein (Pacap)

中文名稱：

大鼠Mzb1重組蛋白
貨號：

CSB-YP701075RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Mzb1重組蛋白
貨號：

CSB-EP701075RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Mzb1重組蛋白
貨號：

CSB-EP701075RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Mzb1重組蛋白
貨號：

CSB-BP701075RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Mzb1重組蛋白
貨號：

CSB-MP701075RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Mzb1
Uniprot No.：

Q561R0
別名：

Mzb1; Pacap; Marginal zone B- and B1-cell-specific protein; Plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; pERp1; Proapoptotic caspase adapter protein
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

22-188
氨基酸序列

DRVSLSATA PTLDDEEKYA SHMPTHLRCD ACRAVAYQMG QHLAKAEAKS HTPDSSGSQE LSESTYTDVL DRTCSQNWQS YGVQEVNQMK RLMGPGLSKG PEPSISVMIT GGPWPNRLSM TCFHYLGEFG EDQIYEAYRQ GHETLEALLC GGTHGSCSQE IPAQREEL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation.; Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.
基因功能參考文獻：
1. It is evident that PACAP-induced prodynorphin mRNA expression is mediated by the activation of the protein kinase A (PKA) pathway. PMID: 20728507
2. Data suggest that exogenous PACAP is able to counteract NMDA-induced toxicity, and that endogenous PACAP exerts a neuroprotective effect in the retina. PMID: 20703829
3. Results indicate that lack of pancreatic PACAP did not aggravate, but rather ameliorated, cerulein-induced pancreatitis. PMID: 20567937
4. These results suggest that PACAP exerts anti-inflammatory, particularly edema-inhibiting effects in allergic contact dermatitis. PMID: 20414744
5. The results suggest that VIP has a role in the neural control of pelvic organ function and activation of VPAC and/or PACAP receptors can modulate the activity of the autonomic neurons innervating pelvic organs. PMID: 20428965
6. Data describe PACAP, vasoactive intestinal polypeptide, and PAC1, VPAC1, VPAC2 transcripts or protein expression in urothelium and detrusor smooth muscle and lumbosacral dorsal root ganglia in NGF-overexpressing and wildtype mice. PMID: 20449688
7. Data show that PACAP neither influenced the survival of JAR cytotrophoblast cells nor affected cellular response to the death-inducing effect of the chemotherapeutic agent methotrexate. PMID: 20449689
8. These data indicate that islet-produced PACAP protects beta-cells from deteriorating action of high glucose and palmitate at least partly by blocking the elevation of UCP2, suggesting an anti-diabetic role for PACAP. PMID: 20461496
9. Results propose an important protective effect of endogenous PACAP-38 against intestinal warm ischemia, which provides basis for further investigation to elucidate the mechanism of this protective effect. PMID: 20387008
10. Results suggest that PACAP plays an important role in the physiological regulation of oxidative stress. PMID: 20387010
11. Data show that the presence of PACAP-38 in the small bowel tissue has a key role in the protection against intestinal cold preservation injury. PMID: 20379803
12. Results demonstrate that, although only the parasympathetic neurons in explant cultured MPGs increase expression of PACAP, both sympathetic and parasympathetic postganglionic neurons in the cultured MPG whole-mount increase expression of ATF-3. PMID: 20407844
13. Endogenous PACAP protects against noxious stimuli in the kidney and PACAP may act as a stress sensor in renal cells as seen in PACAP knockout mice. PMID: 20692466
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亞細胞定位：

Endoplasmic reticulum lumen. Secreted.
蛋白家族：

MZB1 family
數據庫鏈接：

KEGG: rno:291675

STRING: 10116.ENSRNOP00000030810

UniGene: Rn.19595