Recombinant Rat Phenylethanolamine N-methyltransferase (Pnmt)

中文名稱：

大鼠Pnmt重組蛋白
貨號：

CSB-YP018274RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Pnmt重組蛋白
貨號：

CSB-EP018274RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Pnmt重組蛋白
貨號：

CSB-EP018274RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Pnmt重組蛋白
貨號：

CSB-BP018274RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Pnmt重組蛋白
貨號：

CSB-MP018274RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pnmt
Uniprot No.：

P10937
別名：

Pnmt; Phenylethanolamine N-methyltransferase; PNMTase; EC 2.1.1.28; Noradrenaline N-methyltransferase
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-285
氨基酸序列

MDRGSDPKHT AGMDSDSDPG QAEVALAYQR FEPRAYLRNN YAPPRGDLSN PDGVGPWKLR CMAQVFATGE VSGQVLIDIG SGPTIYQLLS ACAHFEDITM TDFLEVNRQE LGLWLREEPG AFDWSVYSQH VCLIEDKGES WQEKERQLRA RVKRVLPIDV HKPQPLGASG LAPLPADALV SAFCLEAVSP DLPSFRQALY HITTLLRPGG NLLFIGALEE SWYLAGEARL SVVPVSEEEV REALVCSGYE VRDLRTYIMP AHLRTGVDDV KGIFFAWAQK IEVQV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Converts noradrenaline to adrenaline.
基因功能參考文獻：
1. These results suggest that increased PNMT gene expression via altered transcriptional activity is a possible mechanism by which prenatal exposure to elevated levels of glucocorticoids may program for hypertension later in life. PMID: 26475702
2. Stress elevated PNMT levels in heart ventricles. PMID: 21777029
3. Findings demonstrate that CoCl(2)-induced ROS have synergistic effects on hormonal and neural activation of the PNMT promoter. PMID: 22007271
4. PNMT gene expression in the rat spleen is exaggerated by stress stimuli, suggesting its role in physiological regulations PMID: 11965360
5. PNMT activates both nicotinic and muscarinic receptors in vivo and in vitro PMID: 12438084
6. PNMT may play a role in the regulation of fetal heart rate prior to development of the adrenal medulla [review] PMID: 12438093
7. Phenylethanolamine N-methyltransferase expression is regulated by cAMP-dependent protein kinase A and protein kinase C signaling pathways PMID: 12438094
8. 15% haemorrhage significantly induced expression of PNMT in the rostral C1 region of ventrolateral medulla PMID: 12782392
9. Glucocorticoid receptors form multimers of Pmnt independent of the DNA binding domain PMID: 12933902
10. expression of the PNMT gene seems to be modulated through competitive binding of phosphorylated Sp1 and MAZ to their consensus elements in the promoter. PMID: 14573768
11. PNMT gene expression and protein levels were increased after repeated stress exposure in stellate ganglia of rats and wild-type mice. The immobilization-induced increase was probably regulated by glucocorticoids. PMID: 16696852
12. The results allow us to propose that in the heart, the immobilization-induced increase in PNMT gene expression is probably not in cardiomyocytes, but in neuronal cells. PMID: 17175506
13. These results suggest that PNMT gene expression is modulated differently in cardiac atria and ventricles and might result in different physiological consequences. PMID: 17356229
14. Real-time quantitative polymerase-chain reaction was performed to quantify relative expression levels of mRNAs for catecholamine biosynthetic enzymes tyrosine hydroxylase, dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase. PMID: 18987458
15. In chronically isolated rats, gene expression levels of phenylethanolamine N-methyltransferase in the adrenal medulla was decreased. PMID: 19112418
16. Data show that voluntary wheel running failed to modify sensitivity to cardiovascular action of oxytocin but resulted in increased gene expression of PNMT in left, but not right, heart atrium in a running activity-dependent manner. PMID: 19120122
17. Altered transcriptional regulation of PNMT is a contributing factor to altered adrenergic function in hypertension. PMID: 19539715
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蛋白家族：

Class I-like SAM-binding methyltransferase superfamily, NNMT/PNMT/TEMT family
數據庫鏈接：

KEGG: rno:24661

STRING: 10116.ENSRNOP00000067392

UniGene: Rn.202604