Recombinant Rat Nuclear receptor subfamily 1 group I member 3 (Nr1i3)

中文名稱：

大鼠Nr1i3重組蛋白
貨號：

CSB-YP874096RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Nr1i3重組蛋白
貨號：

CSB-EP874096RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Nr1i3重組蛋白
貨號：

CSB-EP874096RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Nr1i3重組蛋白
貨號：

CSB-BP874096RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Nr1i3重組蛋白
貨號：

CSB-MP874096RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Nr1i3
Uniprot No.：

Q9QUS1
別名：

Nr1i3; Car; Nuclear receptor subfamily 1 group I member 3; Constitutive androstane receptor; CAR
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-358
氨基酸序列

MTATLTLETM TSEEEYGPRN CVVCGDRATG YHFHALTCEG CKGFFRRTVS KTIGPICPFA GRCEVSKAQR RHCPACRLQK CLNVGMRKDM ILSAEALALR RARQARRRAQ KASLQLSQQQ KELIQTLLGA HTRHVGPMFD QFVQFRPPAY LFSHHRPFQP LAPVLPLLTH FADINTFMVQ QIIKFTKDLP LFRSLTMEDQ ISLLKGAAVE ILHISLNTTF CLQTQNFFCG PLCYKMEDAV HVGFQYEFLE LIIHFHKTLK RLQLQEPEYA LMAAMALFSP DRPGVTQREE IDQLQEEVAL ILNNHIMEQQ SRLQSRFLYA KLMGLLAELR SINSAYSYEI HRIQGLSAMM PLLGEICS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
基因功能參考文獻：
1. nuclear expression virtually disappeared in the late stage of cholestatic injury, after an initial increase PMID: 29204052
2. Metabolism of methiocarb and carbaryl does not alter CAR activity. PMID: 27665777
3. results are the first report that CaR plays an important role in Ca(2+) signaling involved in cardiac fibrosis through the phospholipase C- inositol 3,4,5 phosphate (PLC-IP3) pathway. PMID: 24603056
4. Dissociation of CAR nuclear receptor from thyroid hormone receptors results in down-regulation of hepatic cytochrome P450-PB2 (CYP2B)1. PMID: 24368200
5. CAR nuclear receptors are activated following ethyl tertiary-butyl ether administration leading to tumorigenesis. PMID: 24090815
6. Data show that nuclear import of CAR is regulated by importin/Ran-GTP systems. PMID: 20478346
7. CAR expressed in the hepatic preneoplastic lesions of rats is resistant to nuclear translocation and transactivation of the phenobarbital(PB) responsive enhancer module upon PB treatment. PMID: 15953603
8. Intracellular localization of CAR is determined by the combined effects of nuclear localization signals, the xenochemical response signal, and the cytoplasmic retention region. PMID: 16055207
9. Constitutive CAR gene expression is regulated in part by CTP2B induction. PMID: 16153763
10. In rat hepatocytes CAR was induced by WY14643, a PPARalpha-agonist. A DR1 motif in the CAR promoter was necessary and sufficient for this control. PMID: 18023279
11. Evidence for the involvement of CAR in transcriptional effects upon perfluoroalkyl acid exposure in the rat is reported. PMID: 19162173
12. CAR mRNA levels did not differ in the large-for-gestational-age rats PMID: 19435144
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亞細胞定位：

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton.
蛋白家族：

Nuclear hormone receptor family, NR1 subfamily
數據庫鏈接：

KEGG: rno:65035

STRING: 10116.ENSRNOP00000048836

UniGene: Rn.163229