Recombinant Rat Sterol carrier protein 2 (Scp2)

中文名稱：

大鼠Scp2重組蛋白
貨號：

CSB-YP020856RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Scp2重組蛋白
貨號：

CSB-EP020856RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Scp2重組蛋白
貨號：

CSB-BP020856RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Scp2重組蛋白
貨號：

CSB-MP020856RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Scp2
Uniprot No.：

P11915
別名：

Scp2; Scp-2Non-specific lipid-transfer protein; NSL-TP; EC 2.3.1.176; Propanoyl-CoA C-acyltransferase; SCP-chi; SCPX; Sterol carrier protein 2; SCP-2; Sterol carrier protein X; SCP-X
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-547
氨基酸序列

MPSVALNSPR LPRVFVVGVG MTKFMKPGGE NSRDYPDLAK EAGQKALADR QIPYSAVEQA CVGYVYGEST CGQRAIYHSL GLTGIPIINV NNNCSTGSTA LFMAQQLVQG GLANCVLALG FEKMEKGSLG TKYSDRSNPL EKHIDVLINK YGMSACPFAP QLFGSAGKEH METYGTKVEH FAKIGWKNHK HSVNNPYSQF QDEYSLDEIM KSRPVFDFLT VLQCCPTSDG AAAAIVSSEE FVQKHGLQSK AVEIVAQEMV TDMPSTFEEK SVIKMVGYDM SKEAARKCYE KSGLGPSDVD VIELHDCFST NELLTYEALG LCPEGQGGAL VDRGDNTYGG KWVINPSGGL ISKGHPLGAT GLAQCAELCW QLRGEAGKRQ VPGAKVALQH NLGLGGAAVV TLYRMGFPEA ASSFRTHQIS AAPTSSAGDG FKANLIFKEI EKKLEEEGEE FVKKIGGIFA FKVKDGPGGK EATWVVDVKN GKGSVLPDSD KKADCTITMA DSDLLALMTG KMNPQSAFFQ GKLKIAGNMG LAMKLQSLQL QPDKAKL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.; Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.
基因功能參考文獻：
1. that type II natural killer T cells reactive with autologous SCP2 are implicated in vascular inflammation in the rat model. PMID: 27863214
2. Expression of the SCPx gene is regulated by PPARalpha; mechanism of this regulation occurs mainly through binding and activation of two peroxisomal-proliferator-response element motifs found in the promoter of the SCPx gene. PMID: 12890579
3. MLN64 has roles with StAR, and SCP-2 in regulating bile acid synthesis PMID: 15342684
4. These data are in agreement with the findings that diabetes, a medical condition characterized by high levels of fatty acids in an insulin deficient environment, enhances the hepatic expression of SCPx. PMID: 18187312
亞細胞定位：

[Isoform SCP2]: Peroxisome. Cytoplasm. Mitochondrion.; [Isoform SCPx]: Peroxisome.
蛋白家族：

Thiolase family
組織特異性：

Liver > intestine > brain > lung, colon, stomach, spleen, kidney, heart and ovary.; [Isoform SCPx]: Expressed in liver (at protein level).; [Isoform SCP2]: Expressed in liver (at protein level).
數據庫鏈接：

KEGG: rno:25541

STRING: 10116.ENSRNOP00000015420

UniGene: Rn.31887