Recombinant Rat Neurotensin receptor type 1 (Ntsr1), partial

中文名稱：

大鼠Ntsr1重組蛋白
貨號：

CSB-YP016137RA1
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Ntsr1重組蛋白
貨號：

CSB-EP016137RA1
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Ntsr1重組蛋白
貨號：

CSB-EP016137RA1-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Ntsr1重組蛋白
貨號：

CSB-BP016137RA1
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Ntsr1重組蛋白
貨號：

CSB-MP016137RA1
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ntsr1
Uniprot No.：

P20789
別名：

Ntsr1; Ntsr; Neurotensin receptor type 1; NT-R-1; NTR1; High-affinity levocabastine-insensitive neurotensin receptor; NTRH
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.
基因功能參考文獻：
1. A thermostable variant termed enNTS1 exhibited the best combination of signaling capability and stability upon solubilization with detergents. Several well dispersed (13)CH3-methionine resonances were seen by solution NMR spectroscopy, many of which exhibited chemical shift changes upon the addition of the high affinity agonist peptide, NT8-13. PMID: 29596791
2. Herein potential interaction between NTS1 receptor, dopaminergic D2 receptor and Na(+), K(+)-ATPase was studied.Results indicated that typical and atypical antipsychotic drugs differentially modulate the interaction between neurotensin and Na(+), K(+)-ATPase. PMID: 27586561
3. NTS1 agonists as potentially novel drugs for the treatment of schizophrenia. PMID: 26783230
4. Molecular dynamics simulations of NTS1 in bilayers are in agreement with the ESR data, and point to sites in the receptor where PS could interact with higher affinity PMID: 26926422
5. Molecular dynamics simulation study on the neurotensin peptide receptor NTSR1 with neurotensin bound, with the aim of understanding the structural basis of thermostabilization and activation PMID: 25807267
6. This study demonistrated that Ntsr1 and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain. PMID: 24978951
7. Maternal separation-induced alternations of DNA methylation in the promoter region of NTSR1 in the amygdala may be associated with vulnerability to the development of anxiety disorders and depression in adulthood PMID: 24831231
8. the crystal structure at 2.8 A resolution of Rattus norvegicus NTSR1 in an active-like state, bound to NTS(8-13), the carboxy-terminal portion of NTS responsible for agonist-induced activation of the receptor PMID: 23051748
9. The high-affinity NT receptor may not be involved in ligand binding inhibition to muscarinic receptor by NT. PMID: 20403392
10. NTR1-like immunoreactive GABAergic neurons are widely distributed in the deep layers of the prefrontal cortex. NTR1 may play a role in PFC interneuron regulation by neurotensin. PMID: 15716398
11. Data showed a positive correlation between blood ethanol concentration and higher neurotensin receptor 1 density in putamen and ventral midbrain in High and Low Alcohol Sensitive rat lines. PMID: 16953387
12. Neurotensin 1 receptors play a key role in the regulation of pain signaling in the spinal cord. PMID: 18182046
13. The potentiating effects of neurotensin on DA and 5-HT release in the PFC are regulated by NTR1 receptors, probably located on dopaminergic and serotonergic nerve terminals or axons. PMID: 18835308
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Membrane raft.
蛋白家族：

G-protein coupled receptor 1 family, Neurotensin receptor subfamily, NTSR1 sub-subfamily
組織特異性：

Detected in brain and small intestine.
數(shù)據(jù)庫鏈接：

KEGG: rno:366274

STRING: 10116.ENSRNOP00000035997

UniGene: Rn.200149