Recombinant Rat Neuroserpin (Serpini1)

中文名稱：

大鼠Serpini1重組蛋白
貨號：

CSB-YP867553RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Serpini1重組蛋白
貨號：

CSB-EP867553RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Serpini1重組蛋白
貨號：

CSB-EP867553RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Serpini1重組蛋白
貨號：

CSB-BP867553RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Serpini1重組蛋白
貨號：

CSB-MP867553RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Serpini1
Uniprot No.：

Q9JLD2
別名：

Serpini1; Pi12; Spi17Neuroserpin; Peptidase inhibitor 12; PI-12; Serine protease inhibitor 17; Serpin I1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

17-410
氨基酸序列

TGAA FPDETIAEWS VNVYNHLRAT GEDENILFSP LSIALAMGVM ELGAQGSTLK EIRHSMGYES LKSGEEFSFL RDFSSMVSAE EGQYVMKIAN SLFVQNGFHI NEEFLQMMKM YFNAEVNHVD FSENVAVANY INKWVENYTN SLLKDLVSPG DFDAVTHLAL INAVYFKGNW KSQFRPENTR TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ VLEIPYEGDE ISMMLVLSRQ EVPLATLEPL LKPQLIEEWA NSVKKQKVEV YLPRFTVEQE IDLKDILKAL GVTEIFIKDA NLTAMSDKKE LFLSKAVHKS FIEVNEEGSE AAVASGMIAI SRMAVLFPQV IVDHPFLFLI KNRKTGTILF MGRVMHPETM NTSGHDFEEL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
基因功能參考文獻：
1. neuroserpin has a role in oxygen-glucose deprivation- and reoxygenation-treated rat astrocytes PMID: 25874935
2. The majority of the mutant neuroserpin proteins were found to fold correctly and could still form inhibitory complexes with tissue plasminogen activator (tPA). PMID: 25363759
3. Neuroserpin upregulates in the early period of sustained spinal cord compression. PMID: 23163103
4. Increased expression of neuroserpin is shown to regulate the density of dendritic protrusions and shift morphology to a more immature spine phenotype. PMID: 20648651
5. Although neuroserpin is expressed during late stage of neurogenesis in development, our results suggest that neuroserpin may play some roles in early stage of neurogenesis in adult rat hippocampus. PMID: 20010310
6. novel intracellular serpin from the rat pituitary gland; data suggest raPIT5a may regulate apoptosis in the pituitary by inhibition of granzyme B or GLP IIIa, or members of the caspase enzyme family. PMID: 11935397
7. neuroserpin may play a role in cell communication, cell adhesion, and/or cell migration PMID: 12438159
8. In nerve cells, neuroserpin may regulate the levels of N-cadherin available for construction, maintenance, and control of synapses and synaptic dynamics. PMID: 18092357
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亞細胞定位：

Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Perikaryon.
蛋白家族：

Serpin family
組織特異性：

Detected in adult pituitary and adrenal gland.
數據庫鏈接：

KEGG: rno:116459

STRING: 10116.ENSRNOP00000013905

UniGene: Rn.52632