Recombinant Rat Na (+)/H (+) exchange regulatory cofactor NHE-RF3 (Pdzk1)

中文名稱：

大鼠Pdzk1重組蛋白
貨號：

CSB-YP881315RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Pdzk1重組蛋白
貨號：

CSB-EP881315RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Pdzk1重組蛋白
貨號：

CSB-EP881315RA-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Pdzk1重組蛋白
貨號：

CSB-BP881315RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Pdzk1重組蛋白
貨號：

CSB-MP881315RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pdzk1
Uniprot No.：

Q9JJ40
別名：

Pdzk1; Clamp; Diphor1; Nherf3; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; NHERF-3; C-terminal-linking and modulating protein; Dietary Pi-regulated RNA-1; Diphor-1; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; NaPi-Cap1; PDZ domain-containing protein 1; Sodium-hydrogen exchanger regulatory factor 3
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區(qū)域：

1-523
氨基酸序列

MASTFNPREC KLSKKEGQNY GFFLRIEKDT DGHLVRVIEE GSPAEKAGLL DGDRVLRING VFVDKEEHAQ VVDLVRKSGN SVTLLVLDGD SYEKAVKHQV DLKELDQSPR EPALNEKKPD LGMNGGVETC AQPRLCYLVK EGNSFGFSLK TIQGKKGVFL TDITPQGVAM KAGVLADDHL IEVNGENVEN ASHEEVVEKV TKSGSRIMFL LVDKETARCH SEQKTPFKRE TASLKLLPHQ PRVVVIKKGS NGYGFYLRAG PEQKGQIIKD IEPGSPAEAA GLKNNDLVVA VNGESVEALD HDGVVEMIRN GGDQTTLLVL DKEADRIYSL ARFSPLLYCQ SQELPNGSVK EAPAPISAPL EAPGSATTED VGDHKPKLCR LIKEDDSYGF HLNAIRGQPG SFVKEVQQGG PADKAGLENE DIIIEVNGEN VQDEPYDRVV ERIKSSGEHV TLLVCGKVAY SYFQAKKIPI LSSLADPLVA GPDAKGETEH DSAESTKDSS HPARDRTLSA ASHSSSNSED TVM
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts (via PDZ1 domain) directly with KLHL17; the interaction is important for integrity of actin cytoskeleton structures in neurons.
亞細胞定位：

Membrane; Peripheral membrane protein. Cell membrane.
蛋白家族：

NHER family
組織特異性：

Highly expressed in small intestine and kidney, slightly in the liver. Expression was up-regulated when fed on a low inorganic phosphate diet.
數(shù)據(jù)庫鏈接：

KEGG: rno:65144

STRING: 10116.ENSRNOP00000000107

UniGene: Rn.19842