Recombinant Rat Mitochondrial peptide methionine sulfoxide reductase (Msra)

中文名稱：

大鼠Msra重組蛋白
貨號：

CSB-YP821657RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Msra重組蛋白
貨號：

CSB-EP821657RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Msra重組蛋白
貨號：

CSB-EP821657RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Msra重組蛋白
貨號：

CSB-BP821657RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Msra重組蛋白
貨號：

CSB-MP821657RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Msra
Uniprot No.：

Q923M1
別名：

Msra; Mitochondrial peptide methionine sulfoxide reductase; EC 1.8.4.11; Peptide-methionine; S)-S-oxide reductase; Peptide Met(O) reductase; Protein-methionine-S-oxide reductase; PMSR
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

21-233
氨基酸序列

MGDSSSKVIS AEEALPGRTE SIPVAAKHHV SGNRTVEPFP EGTQMAVFGM GCFWGAERKF WLLKGVYSTQ VGFAGGYTRN PTYKEVCSEK TGHAEVVRVV YRPEHVSFEE LLKVFWENHD PTQGMRQGND CGTQYRSAVY PTSAVQMEAA LKSKEEYQKV LSKHGFGPIT TDIREGQVFY YAEDYHQQYL SKNPDGYCGL GGTGVSCPTA IKK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
基因功能參考文獻：
1. The study provides the first direct evidence for the biological significance of MsrA in microglia-mediated neuroinflammation. PMID: 25602783
2. MsrA probably enhances ATP synthesis by increasing complex IV activity. PMID: 24120970
3. Specific colorimetric microplate assay for testing MsrA activity quickly, based on the fact that MsrA can catalyze the reduction of methyl sulfoxides and simultaneously oxidize dithiothreitol, whose color can be produced by reacting with Ellman's reagent. PMID: 24315642
4. MsrA overexpression in MsrA-depleted cells led to the reduction of increased HO-1 expression, and suppressed nuclear accumulation of Nrf2. PMID: 23036869
5. The data indicate that Msr activity is reduced by obesity and may alter oxidative stress signalling of obesity. PMID: 21726174
6. Methionine sulfoxide reductase A plays a protective role against hypoxia/reoxygenation-induced cell injury. PMID: 14745014
7. Multiple MSRA variants participate in the repair of oxidized proteins in vascular smooth muscle cells mitochondria. PMID: 17907003
8. These observations indicate that MsrA is protective against hypoxia/reoxygenation stress in cardiac myocytes and point to MsrA as an important therapeutic target for ischemic heart disease. PMID: 18083115
9. Up-regulation of the expression of Msra could represent a protective response to the increased oxidative stress in the aging myocardium. PMID: 18996141
10. This suggests an important role for an MSRA catalytic antioxidant cycle for protection of the cytoplasmic compartment against oxidative damage. PMID: 19085252
11. The enzymatic properties of MsrA indeed rely on the activation of the catalytic cysteine to the thiolate anion form that is potentially susceptible to oxidation by hydrogen peroxide. PMID: 19646993
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亞細胞定位：

[Isoform 1]: Mitochondrion.; [Isoform 2]: Mitochondrion.; [Isoform 3]: Mitochondrion.; [Isoform 4]: Cytoplasm.
蛋白家族：

MsrA Met sulfoxide reductase family
組織特異性：

Isoform 2 is ubiquitously expressed.
數據庫鏈接：

KEGG: rno:29447

UniGene: Rn.163306