Recombinant Rat Leptin receptor (Lepr), partial

中文名稱：

大鼠Lepr重組蛋白
貨號：

CSB-YP012871RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Lepr重組蛋白
貨號：

CSB-EP012871RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Lepr重組蛋白
貨號：

CSB-EP012871RA-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Lepr重組蛋白
貨號：

CSB-BP012871RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Lepr重組蛋白
貨號：

CSB-MP012871RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Lepr
Uniprot No.：

Q62959
別名：

Lepr; Fa; Obr; Leptin receptor; LEP-R; OB receptor; OB-R; CD antigen CD295
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity. Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production.; May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3.; Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis.
基因功能參考文獻(xiàn)：
1. Leptin receptor was detected sciatic nerve PMID: 30339059
2. These results suggest that leptin and its receptor may serve significant roles in the pathogenesis of varicocele-induced testicular dysfunction. PMID: 29568885
3. high gonadal and gonadal-white adipose tissue expression of leptin system was observed in the offspring of dams fed a high fat diet during pregnancy and lactation. PMID: 28759941
4. This study showed that the maternal undernutrition rats, the 24h food deprivation group displayed significantly higher hypothalamic leptin receptor (OBRb) mRNA levels than the Fed group PMID: 26702900
5. Results demonstrate that cardiac mitochondria express functional leptin receptors suggesting that intracellularly derived leptin functions as an autocrine factor acting on both cell membrane and mitochondrial receptors. PMID: 26122392
6. LEPR is expressed at the cell surface of atrial, ventricular, and sinus node cardiomyocytes. PMID: 26408544
7. Hipocampal lepr expression was lower in experimental diabetic group than control group. learning performance of the control group was found to be better than the diabetic group. Lepr gene may be related to learning performance in diabetic rats. PMID: 25380550
8. Carotid chemoreceptor afferent projections to leptin receptor containing neurons in nucleus of the solitary tract. PMID: 24905621
9. There is an interrelationship between cannabinoid-1 receptor and ObR pathways. PMID: 24903921
10. The influence of the Lepr(fa/fa) mutation on urinary albumin excretion quantitative trait loci unlinked to LEPR, were identified. PMID: 20159938
11. reduction of leptin up-regulates leptin receptor expression and may affect prefrontal cortex neurons PMID: 24007473
12. NPY and its NPY Y1 receptor play a critical role in reproduction by modulating leptin receptor expression. PMID: 24291064
13. Direct leptin activation of nucleus of the solitary tract slightly increases UCP1 levels, but has little effect on food consumption or body weight. PMID: 24920667
14. Genistein stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle. PMID: 24013029
15. Our results provide evidence that Lrb knockdown selectively in the ARC promotes diet-induced obesity and associated metabolic complications in rats. PMID: 23549406
16. Data suggest leptin/Lepr signal transduction in ventromedial hypothalamic nucleus mediates glucose homeostasis; intraventricular leptin infusion normalizes diabetic hyperglycemia, but this action may not require Lepr. PMID: 23782941
17. Changes are examined in leptin sensitivity by leptin resistance-induced leptin receptor (ObRb) and leptin-related suppressor of cytokine signaling 3 (SOCS3) mRNA levels after 8 weeks of exercise training and/or dietary control of high fat induced obesity PMID: 23669042
18. Data suggest that impairment of leptin/leptin receptor signaling in early life promotes leptin/insulin resistance, modifies hypothalamic microRNA expression pattern, and leads to overweight in adulthood. PMID: 23576026
19. Leptin receptor interacts with rat chromosome 1 to regulate renal disease traits PMID: 22968639
20. Congenic rat strain carrying single QTL derived from the OLETF rat shows severe hyperglycemia when combined with obese phenotype via leptin receptor mutation. PMID: 23304119
21. Maternal running during pregnancy resulted in significant increase in the expression of leptin receptor in offspring, which improved learning memory capability in prepubertal and adult rat pups. PMID: 23028249
22. Diet-induced obesity and related metabolic disorders are possibly correlated with up-regulated expression of MCHR1 and down-regulated expression of OB-Rb in adipose tissue. PMID: 21946196
23. There are three subtypes of Leptin receptors expressed in the male rat anterior pituitary. PMID: 21158112
24. Hypothyroidism decreased ObRb-STAT3 signalling in the hypothalamus and pituitary gland, which likely contributes to the loss of leptin action on food intake and TSH secretion, as previously observed in hypothyroid rats. PMID: 22875962
25. The findings strongly supported the hypothesis that endogenous neuronal leptin receptor signaling in the medial nucleus tractus solitarius contributes to the control of meal-related satiation signaling and overall food intake and body weight regulation. PMID: 22693203
26. The objective of the present study was to investigate the effects of obese type 2 diabetes on bone turnover, bone mass, and bone strength in the Spontaneously Diabetic Torii-Lepr fa rat. PMID: 22038286
27. The medium chain triglyceride diet could decrease body weight gain by increasing Ob-Rb expression in hypothalamus and decreasing NPY level. PMID: 19877509
28. The early and delayed ischemia/reperfusion neuronal damage were accompanied with reduction of leptin receptor expression cerebral ischemia. PMID: 21180167
29. The expression of leptin receptor isoforms was detected in the carotid bodies of type I cells but not type II cells. PMID: 21334312
30. Different leptin receptor expression patterns might partly contribute to age- and gender- related differences in trabecular bone mass PMID: 21452040
31. Leptin receptors had a fast response to cold exposure normalizing the lower levels observed in the leptin-programmed animals and may contribute to the higher thyroid hormone cold responses. PMID: 17951546
32. both endospanins are regulators of postinternalization membrane traffic of the endocytic pathway of OB-R. PMID: 21454707
33. The development of obesity via long-termfeeding of a high-fat diet to rats does not result in cardiac lipotoxicity but promotes the down-regulation of cardiac leptin receptors PMID: 21457721
34. LepRb receptors are highly expressed in the solitary nucleus, dorsal motor nucleus of the vagus and catecholaminergic neurons of the ventrolateral medulla. Co-localization of LepRb and TRHR1 receptor is not observed on individual fibers in the hindbrain. PMID: 20691166
35. The increase of both a and b isoform leptin receptors in prostate ventral lobe is related to development of prostate disease. PMID: 21257164
36. An interaction between CCKAR and OB-Rb in these neurons likely facilitates leptin mediation of short-term satiety. PMID: 21109591
37. studies in leptin receptor deficient rats (homozygotes & heterozygotes Zucker rats) suggest leptin receptor is not required for modulation of serum insulin via Mc4r in pancreas & pancreatic (autonomic) neurons PMID: 20963574
38. Data describe effects of activity-based anorexia on muscle and fat depots by studying ghrelin and leptin receptors. expression. Although PMID: 20600421
39. these data clearly implicate the nucleus of the solitary tract and the hypothalamic retrochiasmatic area as key sites through which brain leptin impacts skeletal muscle via leptin receptors PMID: 20501326
40. Obesity and type 2 diabetes in the BioBreeding diabetes-resistant (BBDR) rat result in islet expansion associated with protection from T1D in female but not male BBDR(lepr-/lepr-,Gimap5-/Gimap5-) congenic rats. PMID: 19996157
41. there was the decreased hypothalamus, liver and skeletal ObRb expression in hyperphagic obese Otsuka Long-Evans Tokushima Fatty rats. PMID: 20171169
42. In addition to the presence of ObR mRNA, ObR protein was shown in both astrocytes and neurons in the rat hypothalamus. PMID: 19747514
43. Influence of leptin on neurotransmitter overflow from the rat brain in vitro PMID: 11786145
44. role in increasing leptin mRNA, gene transcription and promoter activity in obese tats PMID: 11829746
45. presence of the long leptin receptor isoform in the absorptive cells of the small intestine, suggesting that leptin could have a physiological role in the regulation of nutrient absorption PMID: 12010881
46. relative leptin resistance in rat pregnancy is due primarily to increased plasma leptin-binding activity rather than to changes in hypothalamic leptin receptor expression PMID: 12021059
47. Mediates leptin potentiation of thermogenic sympathetic responses to hypothermia PMID: 12145155
48. expression of leptin receptors in rat osteoblasts PMID: 12297277
49. Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis. PMID: 12393625
50. Food deprivation enhanced NPY and suppressed leptin receptor expression in the ARN and PVN of the hypothalamus. Nicotine administration resulted in decreased NPY and increased leptin receptor levels. PMID: 12576193
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相關(guān)疾病：

The fatty (Fa) mutation produces profound obesity of early onset caused by hyperphagia, defective non-shivering thermogenesis, and preferential deposition of energy into adipose tissue.
亞細(xì)胞定位：

Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane.; [Isoform E]: Secreted.
蛋白家族：

Type I cytokine receptor family, Type 2 subfamily
組織特異性：

Isoform B is expressed in kidney, liver, lung, ovary, spleen and uterus. Increased level in uterus during gestation. Isoform A and isoform C are predominantly expressed in cerebral microvessels and choroid plexus, with lower levels in cortex, cerebellum a
數(shù)據(jù)庫鏈接：

KEGG: rno:24536

STRING: 10116.ENSRNOP00000046647

UniGene: Rn.9891