Recombinant Rat KH domain-containing, RNA-binding, signal transduction-associated protein 1 (Khdrbs1)

中文名稱：

大鼠Khdrbs1重組蛋白
貨號：

CSB-YP820982RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Khdrbs1重組蛋白
貨號：

CSB-EP820982RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Khdrbs1重組蛋白
貨號：

CSB-EP820982RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Khdrbs1重組蛋白
貨號：

CSB-BP820982RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Khdrbs1重組蛋白
貨號：

CSB-MP820982RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Khdrbs1
Uniprot No.：

Q91V33
別名：

Khdrbs1; Sam68KH domain-containing; RNA-binding; signal transduction-associated protein 1; GAP-associated tyrosine phosphoprotein p62; Src-associated in mitosis 68 kDa protein; Sam68; p21 Ras GTPase-activating protein-associated p62; p68
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-443
氨基酸序列

MQRRDDPAAR LTRSSGRSCS KDPSGAHPSV RLTPSRPSPL PHRSRGGGGG PRGGARASPA TQPPPLLPPS NPGPDATVVG SAPTPLLPPS ATAAAKMEPE NKYLPELMAE KDSLDPSFTH AMQLLSVEIE KIQKGESKKD DEENYLDLFS HKNMKLKERV LIPVKQYPKF NFVGKILGPQ GNTIKRLQEE TGAKISVLGK GSMRDKAKEE ELRKGGDPKY AHLNMDLHVF IEVFGPPCEA YALMAHAMEE VKKFLVPDMM DDICQEQFLE LSYLNGVPEP SRGRGVSVRG RGAAPPPPPV PRGRGVGPPR GALVRGTPVR GSITRGATVT RGVPPPPTVR GAPTPRARTA GIQRIPLPPT PAPETYEDYG YDDSYAEQSY EGYEGYYSQS QGESEYYDYG HGELQDSYEA YGQDDWNGTR PSLKAPPARP VKGAYREHPY GRY
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. May not be involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species. RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner. In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1. Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4.
基因功能參考文獻：
1. Finally, we detected the variance during regeneration progress through the rat walk footprint test. In summary, all these evidences demonstrated that Sam68 might participate in Schwann cell proliferation partially via PI3K/Akt pathway and also regulate regeneration after sciatic nerve crush. PMID: 27059137
2. Sam68 might be illustrated in the apoptosis of neurons and proliferation of astrocytes after spinal cord injury. PMID: 27236696
3. Sam68 Promotes NF-kappaB Activation and Apoptosis Signaling in Articular Chondrocytes during Osteoarthritis PMID: 26350037
4. Enhanced p62 expression triggers concomitant autophagy and apoptosis in a rat chronic spinal cord compression model. PMID: 24715058
5. p62/ZIP not only plays a key role in scavenging protein aggregates during autophagy, but it is also involved in preventing oxidative injury and alleviating ER stress through the Keap1-Nrf2-ARE signaling pathway during cerebral ischaemia/reperfusion injury PMID: 23782269
6. The A20 zinc-finger (Znf) domain of ZNF216 and the ubiquitin (Ub) UBA domain of p62 are capable of independent binding interactions in forming a ternary complex with a single Ub. PMID: 21923101
7. PI3K and SAM68 are involved in ANG II signaling, and SAM68 is differentially regulated in vascular smooth muscle cells(VSMC) from spontaneously hypertensive rats(SHR). May contribute to enhanced ANG II signaling and altered VSMC growth in SHR. PMID: 14693677
8. Sam68 may accompany and, conceivably, regulate mature mRNAs during nuclear export, somatodendritic transport, and translation. PMID: 14991841
9. Sam68 undergoes activity-responsive translocation to the soma and dendrites of hippocampal neurons in primary culture PMID: 14996936
10. Sam68 suppresses BRK-induced cell proliferation, and regulates intranuclear localization and cell cycle progression PMID: 16179349
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亞細胞定位：

Nucleus. Cytoplasm. Membrane.
蛋白家族：

KHDRBS family
數據庫鏈接：

KEGG: rno:117268

STRING: 10116.ENSRNOP00000066894

UniGene: Rn.92906