Recombinant Rat Interleukin-2 (Il2)

中文名稱：

Recombinant Rat Interleukin-2 (Il2)
貨號：

CSB-EP011629RA
說明書：

MSDS Datasheet
規格：

￥1536
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater?than?95%?as?determined?by?SDS-PAGE.
生物活性：

Not Test
基因名：

Il2
Uniprot No.：

P17108
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

22.4 kDa
表達區域：

21-155aa
氨基酸序列

APTSSPAKETQQHLEQLLLDLQVLLRGIDNYKNLKLPMMLTFKFYLPKQATELKHLQCLENELGALQRVLDLTQSKSFHLEDAGNFISNIRVTVVKLKGSENKFECQFDDEPATVVEFLRRWIAICQSIISTMTQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
基因功能參考文獻：
1. Data indicate that C-rel binding on the interleukin-2 (IL-2) promoter region declined in the aged CD4+T cells. PMID: 24853588
2. our findings indicate a generic and robust stress-induced reduction in plasma IL-12 PMID: 22659252
3. Effects of systemic IL-2 on neurotransmission in several cortical areas is measured by in-vivo microdialysis; IL-2 has dose-dependent effects on depressive-related behavior after delayed but not acute testing, but no effects on anxiety-like behavior. PMID: 21726905
4. The purpose of this study was to evaluate the effect of exhaustive exercise on proteins associated with muscle damage and regeneration, including IL-2, IL-4 and MyoD in muscle and adipose tissue. PMID: 21668966
5. IL-2 neuroprotective action upon retinal ganglion cells in vitro is mediated by Janus kinase and extracellular signal-regulated kinase 1/2 activation. PMID: 21262542
6. In a living cell imaging study, treatment with IL-2 at different concentrations during development of cultured hippocampal neurons induces major changes in dendritic branches, filopodia mobility, and spine density. PMID: 20225203
7. The pIL-2-shRNA interference plasmid could decrease proinflammatory cytokine production of T lymphocytes and protect hepatocytes from apoptosis in allografts. PMID: 19589546
8. IL-2 may participate in the immune rejection in allogeneic liver transplantation. PMID: 18471351
9. effects of IL-2 on contraction and the [Ca2+]i transient of ventricular myocytes are mediated via the cardiac kappa opioid receptor. PMID: 11907831
10. IL-1alpha and IL-2 produce an increase of glucose metabolism in uteri isolated from underfed rats PMID: 12878449
11. Analysis of murine CD28 mutants reveals a correlation between translocation to lipid rafts and costimulation of IL-2 production. PMID: 15280538
12. These results provide new evidence indicating that cytokine mRNA in the brain can be related to elevated plus-maze behavior and that this relationship is site (prefrontal cortex, striatum)- and cytokine mRNA-specific (IL-2). PMID: 15950774
13. hypothalamic IL2 is decreased after intranasal administration of Epithalon PMID: 17152351
14. stress-induced increase in serum IL-6 level and decrease in IL-2 level PMID: 17433709
15. Cell activation in hypothalamus correlated with decreases in the quantity of IL-2-positive cells. PMID: 18264770
16. Data suggest that estradiol effects on T cell IFN-gamma abd IL-2 production afer trauma-hemorrhage are mediated via non-genomic pathway, and which is in turn mediated via ERK, p38, and JNK pathways. PMID: 18343154
17. Data show that inescapable and escapable stressors have different effects on behavior in the modified active avoidance test and on IL-2 levels in brain areas that are known to be involved in emotional processes. PMID: 18628674
18. CD4+CD25+ T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes, suggesting separate pathways of activation by Th1 and Th2 responses. PMID: 18827184
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亞細胞定位：

Secreted.
蛋白家族：

IL-2 family
數據庫鏈接：

KEGG: rno:116562

STRING: 10116.ENSRNOP00000023327

UniGene: Rn.9871