Recombinant Rat Hypoxia-inducible factor 3-alpha (Hif3a)

中文名稱：

大鼠Hif3a重組蛋白
貨號：

CSB-YP867475RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Hif3a重組蛋白
貨號：

CSB-EP867475RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Hif3a重組蛋白
貨號：

CSB-EP867475RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Hif3a重組蛋白
貨號：

CSB-BP867475RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Hif3a重組蛋白
貨號：

CSB-MP867475RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Hif3a
Uniprot No.：

Q9JHS2
別名：

Hif3a; Hypoxia-inducible factor 3-alpha; HIF-3-alpha; HIF3-alpha; HIF3-alpha-1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-662
氨基酸序列

MDWDQDRSST ELRKEKSRDA ARSRRSQETE VLYQLAHTLP FARGVSAHLD KASIMRLTIS YLRMHRLCAA GEWNQVRKEG EPLDACYLKA LEGFVMVLTA EGDMAYLSEN VSKHLGLSQL ELIGHSIFDF IHPCDQEELQ DALTPRPSLS KKKSEAATGR HFSLRMKSTL TSRGRALNLK AATWKVLHCS GHMRAYKPPA QTSPAGSPRS EPPLQCLVLI CEAIPHPASL EPPLGRGAFL SRHSLDMKFT YCDERIAEVA GYSPDDLIGC SAYEYIHALD SDAVSRSIHT LLSKGQAVTG QYRFLARTGG YLWTQTQATV VSGGRGPQSE SIICVHFLIS RVEENGVVLS LEQTEQHTRR PPQLGTSSKK GIPGNSLDPP APRILAFLHP PALSEASLAA DPRRFCSPDL RRLMAPILDG PPTAATPSTP QAARRPQSPL PADLPDQLAV GLENAHRLST ARKNKTMETD LDIAQDPDTP DLEMLAPYIS MDDDFQLNSS EQLPKVHRRP PRTARRPRAR SFHGLSPPIP EATLLPRWGS DPRLNCSSPS KGDPPTAPLT PRTRKRALAQ SSEDKGLELL ETKPPKRSPR LEPGSVLLPP LSLSFLLQGR QLPGNQPDPR APLVDSHEPL GLAPSLLSLY QHEETIQSRN HFLPAAGLAQ TH
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as a transcriptional regulator in adaptive response to low oxygen tension. Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis. May act as a tumor suppressor.
基因功能參考文獻：
1. Hif3a RNA interference and HIF-prolyl hydroxylase inhibition protect cardiomyocytes against anoxia-reoxygenation injury via the HIF signaling pathway PMID: 29660430
2. The association of IPAS with Bcl-x(L) was also observed in living cells by the FLIM-based FRET analysis, indicating direct binding between the two proteins. PMID: 21546903
3. NF-kB activation in PC12 cells upregulates IPAS gene expression without activating HIF-1a and HIF-2a. PMID: 21558328
4. Hypoxia rapidly activates HIF-3alpha mRNA expression PMID: 12824304
亞細胞定位：

Nucleus. Cytoplasm. Nucleus speckle. Mitochondrion.
組織特異性：

Expressed in the perivenous zone of the liver. Expressed in all tissues examined during normoxia. Expressed in brain and lung. Expressed in periportal and perivenous hepatocytes and in endothelial cells of the central vein (at protein level). Expressed in
數據庫鏈接：

KEGG: rno:64345

STRING: 10116.ENSRNOP00000023490

UniGene: Rn.161814