Recombinant Rat Hepatocyte growth factor (Hgf), partial
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中文名稱：大鼠Hgf重組蛋白
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貨號：CSB-EP010327RA-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：HgfHepatocyte growth factor; Hepatopoietin-A; Scatter factor; SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]
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種屬：Rattus norvegicus (Rat)
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蛋白長度：Partial
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表達區域：33-495
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氨基酸序列QKKRRNTL HEFKKSAKTT LTKEDPLVKI KTKKVNSADE CANRCIRNKG FPFTCKAFVF DKSRKRCYWY PFNSMSSGVK KGFGHEFDLY ENKDYIRNCI IGKGGSYKGT VSITKSGIKC QPWNSMIPHE HSFLPSSYRG KDLQENYCRN PRGEEGGPWC FTSNPEVRYE VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT PHRHKFLPER YPDKGFDDNY CRNPDGKPRP WCYTLDPDTP WEYCAIKMCA HSAVNETDVP METTECIKGQ GEGYRGTTNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL RENYCRNPDG AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY MGNLSKTRSG LTCSMWDKNM EDLHRHIFWE PDASKLTKNY CRNPDDDAHG PWCYTGNPLV PWDYCPISRC EGDTTPTIVN LDHPVISCAK TKQLR
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
相關產品
靶點詳情
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功能：Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
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基因功能參考文獻：
- HGF significantly mitigated the severity of pulmonary artery hypertension (PAH) and inhibited inflammation by attenuating the NF-kB signaling in the lungs of PAH rats. PMID: 29442198
- Our results suggest that hUCMSCs can promote ovarian expression of HGF, VEGF, and IGF-1 through secreting those cytokines, resulting in improving ovarian reserve function and withstanding ovarian senescence. PMID: 28279229
- eIf2alpga expression was upregulated during endoplasmic reticulum stress and interfering eIf2alpha expression proportionately down-regulated HGF expression. PMID: 28844859
- VEGF treatment increases expression of HGF in vitro and in vivo and that, based on a series of integrative studies, we suggest that the effects of VEGF are mediated through downstream HGF signaling. PMID: 27036872
- Hepatocyte growth factor (Hgf) plays a crucial role in the formation of the muscular diaphragmatic components by regulating the migration of myogenic progenitor cells into the primordial diaphragm. PMID: 27480986
- Mesenchymal stem cells restore lung vascular permeability and alleviate lung injury in part by maintaining HGF levels. PMID: 27129877
- The mechanism of antifibrogenic action of OBE is hypothesized to proceed via scavenging free radicals and activating liver regeneration by induction of HGF. PMID: 26213907
- Data show that secretion of hepatocyte growth factor (HGF) was elevated, tumour necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 (TGF-beta1) levels were decreased after infusion of mesenchymal stem cells. PMID: 25736907
- HGF induction is a crucial contributor to the acceleration of cell dedifferentiation and growth. PMID: 25793303
- HGF was hardly detectable in normal tympanic membrane; however, a significant increase was noted in its expression starting from the third day after injury throughout the follow-up period, with the highest level on day 05. PMID: 25920966
- p27 haploinsufficiency protects against heart injury by VEGF/HGF mediated cardioprotection and increased angiogenesis through promoting IKK activation. PMID: 25099287
- spleen seemed to exhibit an inhibitory effect on liver regeneration by downregulating HGF and its receptor c-Met in the liver PMID: 25862490
- Mesenchymal stromal cells increased serum and tissue HGF levels, Met tubular expression and prevented the suppression of tubular MSP/RON expression. PMID: 25277788
- Hepatocyte growth factor upregulates nexilin gene expression in cardiomyocytes via JNK pathway. PMID: 25062485
- Studied the preventive and control effect of matrine on transforming growth factor (TGF-beta1) and hepatocyte growth factor (HGF) of liver fibrosis tissue in rats. PMID: 25063067
- Transplanted mesenchymal stem cells expressing human HGF combined with G-CSF potentially offer synergistic therapeutic benefit for the treatment of pulmonary arterial hypertension. PMID: 23933910
- cytoskeletal rearrangement and cell-cell adhesion, such as through VE-cadherin and ZO-1, are candidate mechanisms for the influence of HGF on the blood-brain barrier PMID: 24370951
- these results indicate that HGF activates the cMetAktTGIF signaling pathway, inhibiting CF proliferation and transformation in response to TGFb1 stimulation. PMID: 24840640
- Fibroblasts activated by hepatoma cell supernatant express COX-2 and HGF at higher levels. PMID: 24815169
- HGF/c-Met signaling pathway plays an essential role in the homing of MSCs towards injured liver triggered by intestinal ischemia-reperfusion, and then mediates MSC-induced liver repair. PMID: 24782653
- results indicated that HGF, MMP-9 and TGF-beta1 may participate in the formation and prognosis of hydrocephalus. PMID: 23270462
- the results provide evidence that HGF can accelerate reepithelialization in skin wound healing by dedifferentiation of epidermal cells in a manner related to the b1-integrin/ILK pathway. PMID: 24490163
- This data indicates that hypoxic modulation of satellite cell-mediated angiogenesis involves a reduction in satellite cell HGF expression. PMID: 24122166
- These results strongly suggest that the combined stimulation of IL-6 and glucocorticoids induces the activation of both Reg and HGF genes. PMID: 23954444
- HGF is important in the repair of the dentine-pulp complex potentially participating in several aspects of wound healing. PMID: 23273597
- HGF is a growth factor playing a key role in islet mass increase and hyperinsulinemia in diet-induced obesity rats; the HGF-Met axis may have a role on insulin signaling in the liver PMID: 23024263
- HGF, bFGF and VEGF significantly increased the growth of vascular endothelial cells. PMID: 22361334
- The renal fibrosis of CAAN could be protected by isogenic MSC transplantation, probably via upregulation of HGF and downregulation of TGF-beta1. PMID: 22661380
- The antifibrotic effects of Astragalus mongholicus may be associated with up-regulation of HGF expression and down-regulation of TGF-beta1 expression in rats with unilateral ureteral obstruction. PMID: 19069655
- HGF is a biomarker and mediator in cardioprotection and cardiovascular regeneration [review] PMID: 22318499
- The data showed that the activation of hepatocyte growth factor/c-Met signaling is a major pathway involved type II cell proliferation induced by ultrafine carbon black. PMID: 22245998
- Upregulation of miRNA-29 by HGF and downregulation by TGF-beta take part in the anti- or profibrogenic response of HSC, respectively PMID: 21931759
- in the same stages, hepatocyte growth factor reduces the amount of actin present in the blood testis barrier region, in which occludin levels are highest and modifies the morphology of the actin cytoskeleton network PMID: 21843593
- Hepatocyte growth factor-induced amelioration in renal interstitial fibrosis is associated with reduced expression of alpha-smooth muscle actin and transforming growth factor-beta1 PMID: 22165288
- HGF and VEGF participate in the pathological injury and repair of cerebral tissue in rats with chronic hydrocephalus after subarachnoid hemorrhage. PMID: 21643626
- Both HGF and glial cell line-derived neurotrophic factor (GDNF) have significant neurotrophic effects, but only HGF can promote neurogenesis, angiogenesis, and synaptogenesis and inhibit fibrosis in brains after transient middle cerebral artery occlusion. PMID: 20963849
- Ezrin, HGF and C-met may have positive effects on the carcinogenesis of rat pancreas PMID: 21134835
- VEGF and TGFbeta might modulate HGF signaling to influence route selection during cancer progression PMID: 21075102
- HGF expression following sciatic nerve ligation was found decreased in ipsilateral dorsal root ganglions from day 3 to day 14. AND no significant change in HGF expression was detected in the lumbar spinal cords. PMID: 20814222
- protective effects of GDNF and HGF on brain ischemia were associated with both antiapoptotic and antiautophagic effects; maybe two types of cell death can occur in the same cell at the same time, and GDNF and HGF are capable of ameliorating both pathways PMID: 20175208
- HGF influences the metabolic activity of isolated Leydig cells (ie, uPA and MMP 2 secretion) and increases TGF-beta activity PMID: 19834131
- HGF counteracted the effect of high glucose on protein kinase A and protein kinase G activity. Thus, inhibition of PKA and activation of PKG are involved in the antioxidant role of HGF. PMID: 20466058
- Valsartan alleviates BLM-induced pulmonary fibrosis in rats, possibly by inhibiting the expression of TGF-beta and stimulating the expression of HGF in lung tissues. PMID: 16115399
- HGF may play an important role in the early stages of dental pulp repair. PMID: 17294746
- HGF-induced EPC proliferation is mediated partly via activation of STIM1 PMID: 20404049
- HGF expression was significantly increased in control rats treated with Astragalus mongholicus compared to rats with unilateral ureteral obstruction. PMID: 19292056
- Over-expression of HGF in vascular smooth muscle cells can be helpful for promoting endothelial stem cells differentiation, increasing their migration and proliferation PMID: 19095317
- HGF is expressed in primary sensory neurons from dorsal root ganglia and spinal cord, and may be involved in sensory transmission. PMID: 11744165
- Differential mitogenic effects of single chain hepatocyte growth factor (HGF)/scatter factor and HGF/NK1 following cleavage by factor Xa PMID: 11832492
- results suggest that hepatocellular hypoxia causes inhibition of HGF-mediated proliferation PMID: 11839582
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蛋白家族：Peptidase S1 family, Plasminogen subfamily
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