Recombinant Rat Follicle-stimulating hormone receptor (Fshr), partial

中文名稱：

大鼠Fshr重組蛋白
貨號：

CSB-YP009021RA1
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Fshr重組蛋白
貨號：

CSB-EP009021RA1
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Fshr重組蛋白
貨號：

CSB-EP009021RA1-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Fshr重組蛋白
貨號：

CSB-BP009021RA1
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Fshr重組蛋白
貨號：

CSB-MP009021RA1
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Fshr
Uniprot No.：

P20395
別名：

Fshr; Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
基因功能參考文獻：
1. The results of this study support the notion that by inhibiting eIF5A hypusination, FSH reduces the expression of an LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR mRNA expression by abrogating the inhibitory action of LRBP. PMID: 28605466
2. Data indicate that sustained follicle stimulation by luteinizing hormone (LH) decreases follicle stimulating hormone (FSH) receptor mRNA levels and FSH receptor signaling and inhibits FSH-induced follicular growth. PMID: 23709086
3. In 20-day-old rat Sertoli cells, transmembrane cell PGs, through tethering/activation of PP2A activity exerts regulatory control on both FSH receptor/Gs coupling and ERK phosphorylation. PMID: 23500014
4. Zuoguiyin could improve the ovarian functions during peri-menopause by up-regulating the expression of FSHR. PMID: 20535929
5. The data suggested that, during prepubertal Sertoli cell maturation, the ability of FSH receptor to respond to FSH is significantly augmented and is associated with the robust differentiation of repopulating spermatogonia. PMID: 22850685
6. report of inhibition of FSHR expression by WT1 in ovarian tissue; inhibition probably occurs via direct interaction with the FSHR promoter PMID: 22431408
7. Used immunohistochemistry to study the expression of FSH-R in rat and human ductuli efferentes and the caput, corpus, and cauda epididymis, and by Western blot analysis in the caput and cauda epididymis of rat. PMID: 20467586
8. MyH9 constitutively forms a ternary complex with FSH-R and inactive GDP-bound G alpha h. PMID: 20068007
9. Findings support the concept that thyroid hormone regulates ovarian follicular development and promotes FSH-induced preantral follicular growth through up-regulation of FSHR, a mechanism dependent on the expression and action of oocyte-derived GDF-9. PMID: 19833718
10. Identification of a short linear sequence present in the C-terminal tail of the rat follitropin receptor that modulates arrestin-3 binding in a phosphorylation-independent fashion PMID: 11934883
11. differences in hydrophobic interactions between transmembrane domains 6 and 7 of the rat and human FSH receptors PMID: 12145341
12. downregulation of FSH-FSHR PMID: 12907758
13. FSH transcytosis across the testicular endothelial barrier is receptor-mediated and involves luminal uptake via coated pits, sorting at the level of luminal early endosomes, and transcellular transport through transcytotic tubulo-vesicular organelles PMID: 15050368
14. OCT-1 binds within DHS3 to silence Fshr transcription, an activity that involves members of the GATA family PMID: 15817654
15. FSH up (1.8-fold) regulates its receptor level only in the immature Sertoli cells and not in the adult. PMID: 16406266
16. FSH receptor expression was demonstrated by RT-PCR and Northern and Western blot analyses in the cauda region of rat epididymis PMID: 16598027
17. These data reveal that distal regulatory regions are required for appropriate temporal and spatial Fshr expression and implicate the identified evolutionary conserved regions in transcriptional regulation of Fshr. PMID: 17097219
18. bioneutralization of FSHR has been achieved by targeting its region 285-309 PMID: 17280718
19. Inhibin A is capable of feedback antagonizing FSH action on GCs by reducing FSHR expression at ovarian level via a short feedback loop. Transcriptional factor receptors, such as SF-1, AR and DAX-1 were involved in this regulation. PMID: 18992787
20. Results indicate that the charged amino acids present in follicle stimulating hormone receptor peptide (20-30) are crucial for its follicle stimulating hormone antagonistic activity. PMID: 19152639
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
組織特異性：

Sertoli cells and ovarian granulosa cells.
數(shù)據(jù)庫鏈接：

KEGG: rno:25449

STRING: 10116.ENSRNOP00000022802

UniGene: Rn.162843