Recombinant Rat Docking protein 1 (Dok1)

中文名稱：

大鼠Dok1重組蛋白
貨號：

CSB-YP703072RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Dok1重組蛋白
貨號：

CSB-EP703072RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Dok1重組蛋白
貨號：

CSB-EP703072RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Dok1重組蛋白
貨號：

CSB-BP703072RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Dok1重組蛋白
貨號：

CSB-MP703072RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dok1
Uniprot No.：

Q4QQV2
別名：

Dok1; Docking protein 1; Downstream of tyrosine kinase 1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-480
氨基酸序列

MDGALMEGPL FLQSQRFGTK RWKKTWAVLY PASPHGVARL EFFDHKGSSS GGGRGGSRRL DCKMIRLAEC VSVVPVTVES PPEPGASAFR LDTAQRSHLL AADAASSTAW VQILCRTAFP KGGWALAQTE NPPKFSALEM LENSLYSPTW EGSQFWVTSQ KTEASERCGL QGSYVLRVEA EKLTLLTLGA QSQILEPLLF WPYTLLRRYG RDKVMFSFEA GRRCPSGPGT FTFQTAQGND IFQAVEAAIQ QQKAQGKVGQ GQDITRTDSH DGETEGKMAP TPVPQEPLGS PPALYAEPLD SLRIPPGPSQ DSLYSDPLGS TPAGAGEGVQ RKKPLYWDLY GHVQQQLLKT KLIDSKEDPI YDEPEGLAPA PLRGLYDLPQ EPKDAWWCQA RLKEEGYELP YNPATDDYAV PPPRSSKPTP APKPQGLILP ESGTTAGSGS KGSDTALYSQ VQKSGTPGRW DCGLSRVGND RVGVKSEGST
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
基因功能參考文獻：
1. Dok-1 is the mediator of the antiallergic actions of dexamethasone and as a negative regulator of the MAP kinase pathway and downstream release of inflammatory mediators. PMID: 15608142
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

DOK family, Type A subfamily
數據庫鏈接：

KEGG: rno:312477

STRING: 10116.ENSRNOP00000010020

UniGene: Rn.117974