Recombinant Rat Catalase (Cat)
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中文名稱：Recombinant Rat Catalase(Cat)
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貨號：CSB-EP004563RA-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：Cat; Cas1Catalase; EC 1.11.1.6
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種屬：Rattus norvegicus (Rat)
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蛋白長度：Full Length of Mature Protein
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表達區域：2-527
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氨基酸序列ADSRDPASD QMKQWKEQRA PQKPDVLTTG GGNPIGDKLN IMTAGPRGPL LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRYSKAKVF EHIGKRTPIA VRFSTVAGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDAML FPSFIHSQKR NPQTHLKDPD MVWDFWSLCP ESLHQVTFLF SDRGIPDGHR HMNGYGSHTF KLVNANGEAV YCKFHYKTDQ GIKNLPVEEA GRLAQEDPDY GLRDLFNAIA SGNYPSWTFY IQVMTFKEAE TFPFNPFDLT KVWPHKDYPL IPVGKLVLNR NPANYFAEVE QMAFDPSNMP PGIEPSPDKM LQGRLFAYPD THRHRLGPNY LQIPVNCPYR ARVANYQRDG PMCMHDNQGG APNYYPNSFS APEQQGSALE HHSQCSADVK RFNSANEDNV TQVRTFYTKV LNEEERKRLC ENIANHLKDA QLFIQRKAVK NFTDVHPDYG ARVQALLDQY NSQKPKNAIH TYVQAGSHIA AKGKANL
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
相關產品
靶點詳情
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功能：Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.
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基因功能參考文獻：
- These results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex. PMID: 29847079
- fenofibrate almost completely abolished GM-induced reactive oxygen species generation, which seemed to be mediated at least in part by the restoration of the expression of PPARalphadependent antioxidant enzymes, including catalase and superoxide dismutase (SOD)-1. PMID: 28290603
- These results indicate that CAT expression is significantly decreased in the hippocampi of aged animals and decreased CAT expression may be closely associated with aging. PMID: 27221506
- Catalase promoter region (-185 to +52) that contains binding sites for C/EBP-beta showed an augmentation in the methylation level along with a change in methylation pattern of CpG islands in response to PTU treatment PMID: 26459835
- Data show that nuclear factor erythroid 2-related factor (Nrf2), superoxide dismutase Sod1 and catalase antioxidant systems are downregulated in isolated arteries and vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats (SHRSP). PMID: 26503970
- mitochondria-targeted antioxidant SkQ1 (50 nmol/kg during 5 days) significantly increased the mRNA levels of Nrf2 transcription factor and Nrf2-induced genes encoding antioxidant enzymes SOD1, SOD2, CAT, and GPx4 in rat peripheral blood leukocytes. PMID: 26071777
- Targeted mass spectrometry for the analysis of nutritive modulation of catalase and heme oxygenase-1 expression. PMID: 25639505
- Decrease in Sirtuin1 (SIRT1) and nuclear factor erythroid 2-related factor (Nrf2) and increase in nuclear factor kappa B (NFkappaB) gene expression in diabetes were associated with a decrease in CAT and GPx mRNA expression. PMID: 24740756
- Coronary resistance regulation seems to be more dependent on the hydrogen peroxide that is maintained at low levels by increased catalase activity. PMID: 24669281
- Catalase was found to participate in lead-induced alcohol intake and is elevated in blood following lead exposure. PMID: 23808586
- The marked increased in alcohol intake that follows an alcohol deprivation period is mediated by acetaldehyde generated in the brain by the action of catalase. PMID: 23527889
- Results suggest that the effects of estrogen on the cell-mediated immune responses are mediated through specific estrogen receptors alpha and beta and antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). PMID: 23911387
- The content of catalase protein in mitochondrial extract increased with aging. PMID: 22683338
- Ornithine alpha-ketoglutarate modulates the levels of antioxidants glutathione peroxidase, superoxide dismutase and catalase, as well as lipid peroxidation products in ammonium acetate treated rats PMID: 22905402
- The increased expression of antioxidant catalase, specifically in hippocampal neurons, will provide protection from age-related cognitive decline. PMID: 21942371
- Ang II inhibited catalase (CAT) and peroxisome proliferator-activated receptor gamma (PPAR gamma) protein and mRNA expressions. PMID: 21295034
- Chronic psychosocial isolation attenuated peroxide-metabolizing enzymes, CAT and GPx, and decreased GLR activity. PMID: 20063054
- catalase activities in liver and kidney of diabetic male or female rats were significantly lower than in non-diabetic rats but the reduction was more pronounced in diabetic female rats. PMID: 20830981
- This protein has been found differentially expressed in the lumbar spinal cord from rats submitted to peripheral lesion during neonatal period. PMID: 20387083
- endogenous PGC-1 alpha is a negative regulator of vascular hypertrophy by up-regulating catalase expression and thus reducing reactive oxygen species levels PMID: 19940161
- No significant differences in superoxide dismutase and catalase activities, but MDA was decreased by ghrelin on day 10. Evidence for antioxidant properties of ghrelin in rat testis. PMID: 19891630
- in addition to transrepression of proinflammatory transcription factors, peroxisome proliferator-activated receptor-gamma may also be modulating catalase expression PMID: 12456800
- Levels of Cat mRNA were significantly reduced in congestive heart failure following myocardial infarction. PMID: 14575298
- Catalase activities decreased in the liver and heart of rats with hypothyroidism PMID: 14624470
- Over-expression catalase genes in primary hippocampal or cortical cultures resulted in increased enzymatic activity of the cognate protein. PMID: 14713308
- Changes in post-brain injury/intervention levels of NGF and activity of three major enzymes responsible for ROS scavenging, catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD), was determined in the hippocampus PMID: 15287906
- Medroxyprogesterone acetate and idarubicin both inhibit blood levels of this enzyme PMID: 15372991
- generation of H(2)O(2) and expression of CAT are coordinated and indicative of epidermal differentiation as well as of the role of CAT in repairing redox damage PMID: 15734284
- influence of gender upon activities of catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD) in hypertension PMID: 15773229
- catalase and glutathione peroxidase are downregulated in renal insufficiency PMID: 15777843
- rats subjected to ovariectomy presented a significant increase in brain Na+, K+-ATPase, AChE and CAT activities, but did not change the oxidative stress parameters PMID: 15869839
- Multiple complex formation of C/EBP-beta regulates transcription in the TATA-less catalase promoter. PMID: 16223488
- psychological stressor induces a "priming" effect specifically on the CuZnSOD and CAT activity PMID: 16238459
- Results suggest that amphetamine exposure is associated with an imbalance between superoxide dismutase and catalase activity in the prefrontal cortex, hippocampus and striatum. PMID: 16770742
- Ischemic attack causes a rapid response in hippocampal tissue as well as in the cerebrospinal fluid, represented by an increase in the activity of endogenous antioxidant enzymes SOD and CAT PMID: 17215005
- catalase is a major participant in the defense of 36B10 glioma cells against oxidative stress PMID: 17320761
- mRNA and protein expressions of superoxide dismutase (SOD) and catalase increase after ischemia (I) and reperfusion (R) of the rat liver. PMID: 17524832
- Nimesulide decreased Cat activity significantly in rats subjected to ischemia. PMID: 17564305
- observations are compatible with the presence of endogenous heme-containing catalase with an activity of 825 +/- 15 units, which contributes to mitochondrial protection against endogenous or exogenous H2O2 PMID: 17576767
- Findings strongly support the assumption that catalase plays a significant role in acetaldehyde formation directly in the rat brain. PMID: 17597213
- Even though mRNA expressions of both catalase and Cu-Zn SOD were not changed, the protein levels increased in parallel to activities in the case of another antioxidant, alpha-lipoic acid. PMID: 18008141
- Results describe the activity of superoxide dismutase and catalase at different ages following methylphenidate treatment in young rats. PMID: 18049893
- Elevated catalase levels in hearts of long-term type 1 diabetic rats signals improved recovery of postischemic cardiac function and reduced reperfusion arrhythmia. PMID: 18430061
- Reduced availability of reactive oxygen species by catalase is a key component of neuroprotection against various toxic stimuli PMID: 19302986
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亞細胞定位：Peroxisome.
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蛋白家族：Catalase family
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