Recombinant Rat Calcium/calmodulin-dependent protein kinase kinase 1 (Camkk1)

中文名稱：

Recombinant Rat Calcium/calmodulin-dependent protein kinase kinase 1(Camkk1)
貨號：

CSB-YP004472RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat Calcium/calmodulin-dependent protein kinase kinase 1(Camkk1)
貨號：

CSB-EP004472RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat Calcium/calmodulin-dependent protein kinase kinase 1(Camkk1)
貨號：

CSB-EP004472RA-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat Calcium/calmodulin-dependent protein kinase kinase 1(Camkk1)
貨號：

CSB-BP004472RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat Calcium/calmodulin-dependent protein kinase kinase 1(Camkk1)
貨號：

CSB-MP004472RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Camkk1
Uniprot No.：

P97756
別名：

Camkk1; Calcium/calmodulin-dependent protein kinase kinase 1; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; EC 2.7.11.17; CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區(qū)域：

1-505
氨基酸序列

MERSPAVCCQ DPRAELVERV AAISVAHLEE AEEGPEPASN GVDPPPRARA ASVIPGSASR PTPVRPSLSA RKFSLQERPA GSCLEAQVGP YSTGPASHMS PRAWRRPTIE SHHVAISDTE DCVQLNQYKL QSEIGKGAYG VVRLAYNERE DRHYAMKVLS KKKLLKQYGF PRRPPPRGSQ APQGGPAKQL LPLERVYQEI AILKKLDHVN VVKLIEVLDD PAEDNLYLVF DLLRKGPVME VPCDKPFPEE QARLYLRDII LGLEYLHCQK IVHRDIKPSN LLLGDDGHVK IADFGVSNQF EGNDAQLSST AGTPAFMAPE AISDTGQSFS GKALDVWATG VTLYCFVYGK CPFIDEYILA LHRKIKNEAV VFPEEPEVSE ELKDLILKML DKNPETRIGV SDIKLHPWVT KHGEEPLPSE EEHCSVVEVT EEEVKNSVKL IPSWTTVILV KSMLRKRSFG NPFEPQARRE ERSMSAPGNL LLKEGCGEGG KSPELPGVQE DEAAS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
基因功能參考文獻：
1. Site-directed mutagenesis analysis revealed that Leu(358) in CaMKKbeta/Ile(322) in CaMKKalpha confer, at least in part, a distinct recognition of AMPK but not of CaMKIalpha. PMID: 27151216
2. CaMKKalpha and CaMKKbeta are capable of phosphorylating and activating CaMKIV in living cells. PMID: 26050738
3. Recombinant CaM-KK alpha exhibits a high calcium/calmodulin-dependent activity with a weak autonomous activity. PMID: 11705382
4. Translocation of CaMKI-alpha into the nucleus involves a conserved sequence located within the catalytic core. Mutation of this sequence partially blocks nuclear entry of an export-impaired mutant of CaMKI-alpha. PMID: 15147908
5. ERK activation and neurite outgrowth in response to depolarization are mediated by CaMKK activation of CaMKI PMID: 15150258
6. Lkb1 and CaMKKalpha function as Snf1 protein kinase kinases, in a cascade that is highly conserved in mouse and yeast PMID: 15831494
7. CaMKII(alpha) expression levels in hippocampus of chronic epileptic rats may be related with their impaired spatial learning and memory. PMID: 18710651
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Protein kinase superfamily, Ser/Thr protein kinase family
組織特異性：

Mostly expressed in the brain with higher levels in cortex and hippocampus. Lower expression levels were detected in striatum, nucleus accumbens and cerebellum (at protein level). Abundant in forebrain, weaker in cerebellum and also detected in thymus and
數(shù)據(jù)庫鏈接：

KEGG: rno:60341

STRING: 10116.ENSRNOP00000025009

UniGene: Rn.4851