Recombinant Rat A-kinase anchor protein 12 (Akap12), partial

中文名稱：

Recombinant Rat A-kinase anchor protein 12(Akap12) ,partial
貨號：

CSB-YP732522RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat A-kinase anchor protein 12(Akap12) ,partial
貨號：

CSB-EP732522RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat A-kinase anchor protein 12(Akap12) ,partial
貨號：

CSB-EP732522RA-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat A-kinase anchor protein 12(Akap12) ,partial
貨號：

CSB-BP732522RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat A-kinase anchor protein 12(Akap12) ,partial
貨號：

CSB-MP732522RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Akap12
Uniprot No.：

Q5QD51
別名：

Akap12A-kinase anchor protein 12; AKAP-12
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
基因功能參考文獻(xiàn)：
1. HSPA12B overexpression interacts with AKAP12 and downregulate TXNIP in diabetic rats following acute myocardial infarction. PMID: 28281242
2. SSeCKS play an important role in sciatic nerve fibers and neurons in spinal cord and dorsal root ganglion during inflammation. PMID: 24623461
3. Dynamic temporal changes in SSeCKS and Src expression may modulate angiogenesis and cerebral edema formation after focal cerebral ischemia. PMID: 21334414
4. Data show that SSeCKS can regulate LPS-induced TNF-alpha secretion through beta-1,4-GalT-I in rat primary astrocytes. PMID: 21573722
5. study delineates that SSeCKS may be important for host defenses in spinal inflammation and suggests a valuable molecular mechanism by which astrocytes modify neuronal viability during pathological states PMID: 20204485
6. Data show that SSeCKS is involved in the endothelial hyperpermeability induced by IL-1beta and TNF-alpha in inflammatory process. PMID: 20454828
7. Results suggest that SRC-suppressed C kinase substrate (SSeCKS) might be critical for the activation of astrocytes in neuropathic pain. PMID: 19937403
8. Platelet-activating factor can upregulate the expression of SSeCKS mRNA in a dose- and time-dependent manner in rat pulmonary microvascular endothelial cells. PMID: 20367900
9. SSeCKS upregulated in astrocytes in experimental autoimmune encephalomyelitis (EAE); understanding the mechanism of SSeCKS in the pathogenesis of EAE may contribute to the development of new therapeutic strategies against EAE and multiple sclerosis PMID: 20155814
10. signaling component essential for IL-17F-induced endothelial hyperpermeability PMID: 19577259
11. In long-term SSeCKS-reduced Schwann cells, cell morphology changed and myelin gene expression induced by cAMP was accelerated. Myelination was also enhanced in SSeCKS-suppressed Schwann cells co-culture with dorsal root ganglion (DRG). PMID: 19757038
12. a role in mitogen-induced cytoskeletal reorganization PMID: 12083796
13. SSeCKS functions in PDGF-BB-, LPA-, EPA-, and NaB-mediated cell signaling PMID: 12372401
14. alternately targeted anchoring protein isoforms provide a mechanism for genetic control of signaling specificity by AKAP12 PMID: 15496411
15. Transfected rat SSeCKS can suppress Src-induced oncogenesis in 3T3 cells by modulating gene expression downstream of Src kinase activity. PMID: 16638134
16. SSeCKS modulate endothelial cells adhesion and spreading by reorganization of the actin cytoskeleton. PMID: 17482576
17. SSeCKS is located downstream of PKC; SSeCKS and PKC are both necessary for LPS-induced stress fiber formation. PMID: 17551670
18. TNF-alpha induced rapid phosphorylation of protein kinase C substrates in C6 glioma cells, and upregulated SSeCKS expression in a time and concentration dependent manner. PMID: 17592532
19. SSeCKS could be detected in the whole brain of developing rat embryos and reached its peak at 1 week after birth, while during mature period, its level was decreasing PMID: 17873283
20. that SSeCKS is involved in the lipopolysaccharide-induced TNF-alpha expression in astrocytes mediated by protein kinase C PMID: 17873284
21. LPS could induce up-regulation of SSeCKS, and methylprednisolone sodium succinate inhibited the increase of SSeCKS mRNA induced by LPS. PMID: 18279585
22. participates in the adaptive response to peripheral nerve injury and may be associated with regeneration PMID: 18384053
23. SSeCKS modulate Schwann cells adhesion, spreading and migration by reorganization of the actin cytoskeleton. PMID: 18979197
24. These results indicate that Cited2 and Akap12 are silenced in radiation-induced osteosarcomas, and therefore are novel candidate tumor-suppressor genes of this tumor. PMID: 19825367
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亞細(xì)胞定位：

Cytoplasm, cytoskeleton. Membrane; Lipid-anchor.
數(shù)據(jù)庫鏈接：

KEGG: rno:83425

STRING: 10116.ENSRNOP00000057494

UniGene: Rn.122094